Results 71 to 80 of about 57,136 (306)

Tubing cutter [PDF]

, 1972
Replacement of opposing smooth rollers with appropriately grooved rollers in manual tubing cutter allows smooth severance of tubing of different diameters and eliminates raised lip around cut ...
Giandomenico, A.
core   +1 more source

On the Amount of the Involute Profile removed by Rack-shaped Cutters

Transactions of the Japan Society of Mechanical Engineers, 1943
種々の圧力角を有するラック型カッタによつて受けるインボリュート歯車の切下げ量とカッタの歯高の関係を精密に計算すべき式を導き、この式によつてこれ等の関係を與へる近似式を求め、更に10°a30°の範囲の圧力角のカッタに対し少くも小数第7桁迄は正しい数値表を計算して與へる。
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Spacecraft separation system for spinning vehicles and/or payloads Patent [PDF]

, 1966
Stage separation system for spinning vehicles and ...
Parker, O. J., Salmirs, S.
core   +1 more source

Overlooked gall-inducing moths revisited, with the description of Andescecidium parrai gen. et sp. n. and Oliera saizi sp. n. from Chile (Lepidoptera, Cecidosidae) [PDF]

, 2018
There are still many gall systems associated with larvae of Lepidoptera in which the true gall-inducers have not been identified to species. Reports on misidentification of gall inducers have been recurrent for these galls, particularly in complex gall ...
Davis, Donald, Gonçalves, Gislene L., Mainardi, Marina D., Moreira, Gilson R. P., San Blas, Diego German, Silva, Gabriela T., Vargas, Héctor A.   +6 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Numerical Simulation Study on the Rock Breaking Effect of Multiple Axe-Shaped Cutters in Rotary Percussion Drilling

Shiyou jixie
The compatibility of percussion tools， PDC cutter types and hard rock formations is a key factor in extending the service life of percussion tools and drill bits and achieve the best rock breaking effect， but it has been rarely studied.
Leng Youheng, Wang Lixin, Chen Pengyu, Liu Ronghe, Xi Yan   +4 more
doaj   +1 more source

Modeling and Simulation Research of Ball End Mill Rake Face

Chemical Engineering Transactions, 2016
According to the structure of the ball end mill and the cutter grinding principle, a mathematic model related to the ball blade rake face and circumference blade rake face was established.
S. Li
doaj   +1 more source