Results 61 to 70 of about 57,136 (306)
Rock-breaking experiments and simulations of shaped cutters in hard rock formations
Natural Gas Industry BTo address the challenges of rapid bit failure and high drilling costs associated with hard limestone in Sichuan Basin of China, we conducted rock-breaking experiments and simulations of shaped (cylindrical, ridge, and chopper) cutters.
Yang Guan +3 more
doaj +1 more source
Agronomy, 2022 The reciprocating cutting system is one of the key parts of a tea harvester; and its cutting performance directly determines the cutting power consumption and harvesting quality of the machine.
Zhe Du +5 more
doaj +1 more source
Grinding arrangement for ball nose milling cutters [PDF]
, 1974 A grinding arrangement for spiral fluted ball nose end mills and like tools includes a tool holder for positioning the tool relative to a grinding wheel.
Burch, C. F.
core +1 more source
Projekt for manufacturing of gears for Company Stab spol. s r. o. [PDF]
, 2020 Diplomová práca opisuje projekt na založenie novej divízie pre firmu ktorá sa zaoberá generálnymi opravami strojov. V prvej časti práce je rozoberaná teoretická časť o výrobnom procese ozubenia a ekonomická časť tejto práce. Hlávne časti práce sú analýza
Štefan Staník
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Valve for waste collection and storage [PDF]
, 1990 A method and valve apparatus for collection of fecal matter designed to operate efficiently in a zero gravity environment is presented. The system comprises a waste collection area within a body having a seat opening.
Thornton, William E., Jr. +1 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source