Results 81 to 90 of about 57,136 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

A fisheries acoustic multi-frequency indicator to inform on large scale spatial patterns of aquatic pelagic ecosystems [PDF]

open access: yes, 2013
Fisheries acoustic instruments provide information on four major groups in aquatic ecosystems: fish with and without swim bladder (tertiary and quaternary consumers), fluidlike zooplankton (secondary consumers) and small gas bearing organisms such as ...
Bergen, Laurent, Trenkel, Verena
core   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Experimental and Simulation Study on the Ditching and Backfilling Characteristics of a 3DGZ-50A Self-Propelled Orchard Ditching Machine

open access: yesHorticulturae
The characteristics of soil ditching and backfilling are crucial for orchard ditching operations. However, experimentally investigating the dynamic ditching and backfilling process is currently not feasible.
Mengmeng Niu   +6 more
doaj   +1 more source

Experimental study on the influence of cutter shape on cutter wear for hard rocks

open access: yesIOP Conference Series: Earth and Environmental Science, 2021
Hongsu Ma   +4 more
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Lunar penetrometer Patent [PDF]

open access: yes, 1967
Development and characteristics of pentrometer for measuring physical properties of lunar ...
Beswick, A. G.   +2 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Mechanical properties and rock-breaking effects of ridge-shaped PDC teeth

open access: yesJin'gangshi yu moliao moju gongcheng
Objectives: With the depletion of easily recoverable oil reservoirs, the focus of oil and gas exploration and development in China has shifted to "two deeps and non-conventional" oil and gas fields.
Zhitao XIE   +4 more
doaj   +1 more source

Method for waste collection and storage [PDF]

open access: yes, 1990
A method for collection of fecal matter designed to operate efficiently in a zero gravity environment was invented. The system consists of a waste collection area within a body having a seat opening.
Thornton, William E., Jr.   +1 more
core   +1 more source

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