Results 81 to 90 of about 998,789 (338)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Numerical Simulation Study on the Rock Breaking Effect of Multiple Axe-Shaped Cutters in Rotary Percussion Drilling

Shiyou jixie
The compatibility of percussion tools， PDC cutter types and hard rock formations is a key factor in extending the service life of percussion tools and drill bits and achieve the best rock breaking effect， but it has been rarely studied.
Leng Youheng, Wang Lixin, Chen Pengyu, Liu Ronghe, Xi Yan   +4 more
doaj   +1 more source

Modeling and Simulation Research of Ball End Mill Rake Face

Chemical Engineering Transactions, 2016
According to the structure of the ball end mill and the cutter grinding principle, a mathematic model related to the ball blade rake face and circumference blade rake face was established.
S. Li
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Design optimization of TBM disc cutters for different geological conditions [PDF]

, 2015
A novel optimization methodology for the disc cutter designs of tunnel boring machines (TBM) was presented. To fully understand the characteristics and performance of TBM cutters, a comprehensive list of performance parameters were investigated ...
Liu, Jingsheng, Xia, Yimin, Zhang, Kui
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Experimental and Simulation Study on the Ditching and Backfilling Characteristics of a 3DGZ-50A Self-Propelled Orchard Ditching Machine

Horticulturae
The characteristics of soil ditching and backfilling are crucial for orchard ditching operations. However, experimentally investigating the dynamic ditching and backfilling process is currently not feasible.
Mengmeng Niu, Huawei Yang, Qingyi Zhang, Peng Qi, Shaowei Wang, Huimin Fang, Hongbo Wen   +6 more
doaj   +1 more source

Multi-step self-guided pathways for shape-changing metamaterials [PDF]

, 2018
Multi-step pathways, constituted of a sequence of reconfigurations, are central to a wide variety of natural and man-made systems. Such pathways autonomously execute in self-guided processes such as protein folding and self-assembly, but require external
Alberico Sabbadini, B Wei, C Coulais, C Coulais, C Coulais, C Coulais, C Coulais, CM Dobson, Corentin Coulais, D Mousanezhad, E Winfree, Fré Vink, J Rogers, JN Grima, JT Overvelde, JT Overvelde, K Bertoldi, K Bertoldi, M Stern, Martin van Hecke, MB Pinson, MK Blees, Q Chen, R Gatt, RF Shepherd, S Felton, S Waitukaitis, S Xu, SD Huber, T Mullin, V Zykov, Y Cho, Y Tang, Y Zhang, Z Zeravcic   +34 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source