Results 81 to 90 of about 1,451,088 (294)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Reaching for Home: Global Learning on Family Reintegration in Low and Lower-Middle Income Countries [PDF]

open access: yes, 2013
This inter-agency, desk-based research aims to arrive at a clearer understanding of reintegration practices for separated children in low and lower-middle income countries.
Joanna Wedge
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Shared Agency: Replies to Ludwig, Pacherie, Petersson, Roth, and Smith

open access: yesJournal of Social Ontology, 2014
These are replies to the discussions by Kirk Ludwig, Elizabeth Pacherie, Björn Petersson, Abraham Roth, and Thomas Smith of Michael E. Bratman, Shared Agency: A Planning Theory of Acting Together (Oxford University Press, 2014).
Michael E. Bratman
doaj  

Shared agency in information behaviour research: Human–Nonhuman interactions

open access: yesInformation Research: An International Electronic Journal
Introduction. This study examines shared agency in information behaviour, advancing a post-anthropocentric perspective that recognises how humans co-participate with technological, biological, and environmental entities when interacting with information.
Niloofar Solhjoo   +2 more
doaj   +1 more source

Performing weight change : a performative reading of reality-making through a relationship of meaning and doing : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in English at Massey University [PDF]

open access: yes, 2009
Reading the reality-making processes that create bodies in weight change performances challenges us to understand the relationships between meanings and actions, or between discourses and materiality. This study uses a performative model to elaborate how
Caseley, Allyson June
core  

The experience of immediacy: emotion and enlistment in fact-based theatre [PDF]

open access: yes, 2011
This article discusses emotion as a strategy of political agency in post-Thatcherite documentary theatre. The 1990s saw a renaissance in theatre writing based in directness and immediacy but based in two quite different forms of drama, In-Yer-Face ...
Taylor, Lib
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Bratman, Searle, and Simplicity. A comment on Bratman, Shared Agency: A Planning Theory of Acting Together

open access: yesJournal of Social Ontology, 2014
Michael Bratman’s work is established as one of the most important philosophical approaches to group agency so far, and Shared Agency, A Planning Theory of Acting Together confirms that impression. In this paper I attempt to challenge the book’s central
Björn Petersson
doaj  

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