Results 81 to 90 of about 2,717,694 (292)

Sharing a Stage in the Arena of Agency

Erasmus Studies
Abstract Exactly five hundred years ago today, Erasmus engaged with Martin Luther in a debate on free will that continues to inspire, even if it evokes a notion of freedom that is no longer ours in every respect. Emphasising the need for a common-sense reading of Holy Scripture that did not require making conjectures about the existence of hidden ...
openaire   +1 more source

Practical Intersubjectivity and Normative Guidance: Bratman on Shared Agency

Journal of Social Ontology, 2014
In an important new book on shared agency, Michael Bratman develops an account of the normative demand for the coordination of intentions amongst participants in shared agency. Bratman seeks to understand this form of normative guidance in terms of that
Abraham Sesshu Roth
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Shared news: Issue 4, March 2003 / Eastern Health Shared Services

, 2003
EHSS ...
Eastern Health Shared Services (EHSS)
core  

Shared goals in science education: youth agency across three national systems

Eesti Haridusteaduste Ajakiri
Loodusteadusliku hariduse puhul puutuvad eri riigid pidevalt kokku probleemiga, kuidas säilitada noorte huvi loodusainete vastu, tagades samas, et nende ainepõhised nõuded saaksid rangelt täidetud.
Angie Valbuena Rojas, Barbara Schneider, Hannah Locke   +2 more
doaj   +3 more sources

Transmission of carbapenemase-producing Enterobacter in Ontario, Canada: a retrospective genomic analysis

Emerging Microbes and Infections
Carbapenemase-producing Enterobacter (CP-Ent) are the third most prevalent species of CP-Enterobacteriaceae worldwide and exhibit greater strain diversity than other CP-species.
Conrad Izydorczyk, Robyn Lee, Laura Mataseje, George R. Golding, Thomas A. Edge, Rachel Boyd, Tom Braukmann, Amanda Carroll, Kevin Katz, Robert Kozak, Alainna J. Jamal, Derek R. MacFadden, Tony Mazzulli, Roberto Melano, Samira Mubareka, Samir Patel, Susan M. Poutanen, David Richardson, Nicholas Waglechner, Allison McGeer   +19 more
doaj   +1 more source

Deliberative Democracy, Public Work, and Civic Agency

Journal of Deliberative Democracy, 2014
This essay locates deliberation and deliberative theory as an important strand in a larger interdisciplinary and political movement, civic agency. The civic agency movement, and its related politics, a politics of civic empowerment, include a set of ...
Harry C. Boyte
doaj   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Shared news: Issue 2, July 2002 / Eastern Health Shared Services

, 2002
EHSS ...
Eastern Health Shared Services (EHSS)
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source