Results 101 to 110 of about 205,273 (284)

Sharing a Stage in the Arena of Agency

Erasmus Studies
Abstract Exactly five hundred years ago today, Erasmus engaged with Martin Luther in a debate on free will that continues to inspire, even if it evokes a notion of freedom that is no longer ours in every respect. Emphasising the need for a common-sense reading of Holy Scripture that did not require making conjectures about the existence of hidden ...
openaire   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Prosperity through people: economic development strategy for the East Midlands 2000 to 2010 [PDF]

, 2000
This strategy is a route-map of the East Midlands’ economic development to 2010. Prepared by East Midlands Development Agency (emda), with extensive input from partners, it provides a framework of priorities within which the region would work towards a ...
East Midlands Development Agency
core  

An agency-promoting learning arena for developing shared work practices

, 2017
Despite the emerging recognition of the pivotal role played by professional agency within work contexts, little is known about how agency is promoted and enacted in organised work-related learning settings.
Vähäsantanen, Katja, Anneli Eteläpelto, Päivi Kristiina Hökkä, Eteläpelto, Anneli, Katja Vähäsantanen, Paloniemi, Susanna, Susanna Paloniemi, Hökkä, Päivi   +7 more
core   +1 more source

Informazioni ambientali sempre più condivise

GEOmedia, 2010
SEIS: Shared Enviroment and Information System The Shared Environmental Information System (SEIS) is a collaborative initiative of the European Commission and the European Environment Agency (EEA) to establish together with the Member States an ...
Mauro Salvemini
doaj   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Preregistration for Studies of Bratmanian Shared Agency

Preregistration protocol for the first of several experimental philosophical (xphi) studies on the norms and behaviors surrounding Bratmanian Shared Agency as a plausible alternative to game theoretic and joint-attentional accounts of ...
Matthew Rachar, Javier Gomez-Lavin
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source