Results 91 to 100 of about 205,273 (284)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Role of shared identity and agency trust in online voting among Finnish citizens [PDF]
This study examined the impact of shared identity and agency trust, governmental vs. third party, on Finnish citizens' intention to vote online. Using the integrated model of shared identity and trust as a theoretical lens, a within-subject quasi ...
Virtanen Seppo +2 more
core +3 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cooperation: The Ethics of Shared Agency
, 2020 Picture yourself at a Parisian café, gazing at people walking down the street. At first, they seem to be typical Parisians going about their own business. Until you realize, as you spot cameras, that they are all actors on a movie set.
Salomone-Sehr, Jules F +1 more
core
Voice and Agency: Empowering women and girls for shared prosperity [PDF]
, 2014 This document presents Voice and Agency: Empowering women and girls for shared prosperity is a major new report by the World Bank that shines a spotlight on the value of voice and agency, the patterns of constraints that limit their realization, and the ...
Luceth X. Ndhlovu +8 more
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Shared Agency: A Planning Theory of Acting Together (Michael E. Bratman) [PDF]
, 2016 Shared agency eskala txikiko ekintza kolektiboari buruzko lana da, jar- duera sozialak ekite indibidualarekin daukan harremanaren ingurukoa.
Díaz, Zvonko, Zvonko Díaz
core +1 more source
Computers in Human Behavior: Artificial HumansVirtual gaming worlds support rich social interaction in which players use avatars to collaborate, compete, and communicate across distance. Motivated by the increasing reliance on mediated social contact, this research examined whether virtual shared ...
Ruoyu Niu, Mengzhu Huang, Rixin Tang
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Cahiers Mondes Anciens, 2019 Agamemnon’s excuses in book 19 of the Iliad have been considered very problematic for the understanding of action and its attribution to several agents in Homer. In this paper, I analyze how the king seeks to convince his audience by presenting his deeds
Manon Brouillet
doaj +1 more source