Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis [PDF]
Viruses, 2019 Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas).
Ian N Moore, Donna Perry, Mahnaz Minai
exaly +7 more sources
The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [PDF]
Journal of VirologyStress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay.
Ayisha A. Lavender +6 more
doaj +3 more sources
Development and Characterization of a cDNA-Launch Recombinant Simian Hemorrhagic Fever Virus Expressing Enhanced Green Fluorescent Protein: ORF 2b’ Is Not Required for In Vitro Virus Replication [PDF]
Viruses, 2021 Simian hemorrhagic fever virus (SHFV) causes acute, lethal disease in macaques. We developed a single-plasmid cDNA-launch infectious clone of SHFV (rSHFV) and modified the clone to rescue an enhanced green fluorescent protein-expressing rSHFV-eGFP that ...
Yingyun Cai, Shu Qìng Yú, Ying Fang
exaly +4 more sources
Insertion position as well as the inserted TRS and gene sequences differentially affect the retention of foreign gene expression by simian hemorrhagic fever virus (SHFV) [PDF]
Virology, 2018 Recombinant SHFV infectious cDNA clones expressing a foreign gene from an additional sg mRNA were constructed. Two 3' genomic region sites, between ORF4' and ORF2b and between ORF4 and ORF5, were utilized for insertion of the myxoma M013 gene with a C-terminal V5 tag followed by one of the three inserted transcription regulatory sequences (TRS), TRS2',
Margo A Brinton, Rachel L Graham
exaly +4 more sources
Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus [PDF]
Viruses, 2018 Simarteriviruses (Arteriviridae: Simarterivirinae) are commonly found at high titers in the blood of African monkeys but do not cause overt disease in these hosts.
Connor R. Buechler +12 more
doaj +5 more sources
Specific Detection of Two Divergent Simian Arteriviruses Using RNAscope In Situ Hybridization [PDF]
PLoS ONE, 2016 Simian hemorrhagic fever (SHF) is an often lethal disease of Asian macaques. Simian hemorrhagic fever virus (SHFV) is one of at least three distinct simian arteriviruses that can cause SHF, but pathogenesis studies using modern methods have been scarce ...
Shu Qìng Yú +2 more
exaly +3 more sources
High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population [PDF]
PLoS ONE, 2014 Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge.
Adam L Bailey +2 more
exaly +2 more sources
Novel, Divergent Simian Hemorrhagic Fever Viruses in a Wild Ugandan Red Colobus Monkey Discovered Using Direct Pyrosequencing [PDF]
PLoS ONE, 2011 Simian hemorrhagic fever virus (SHFV) has caused lethal outbreaks of hemorrhagic disease in captive primates, but its distribution in wild primates has remained obscure.
Michael Lauck +2 more
exaly +2 more sources
Analysis of Simian Hemorrhagic Fever Virus (SHFV) Subgenomic RNAs, Junction Sequences, and 5′ Leader
Virology, 1995 Full-length simian hemorrhagic fever virus (SHFV) genome RNA (about 15 kb in length) and six subgenomic RNAs, ranging in size from 0.65 to 4.7 kb, were detected by Northern blot hybridization in MA104 cytoplasmic extracts with a 3' genomic antisense probe.
Zeng, L. +3 more
exaly +3 more sources
Wildlife nidoviruses: biology, epidemiology, and disease associations of selected nidoviruses of mammals and reptiles. [PDF]
mBio, 2023 Wildlife is the source of many emerging infectious diseases. Several viruses from the order Nidovirales have recently emerged in wildlife, sometimes with severe consequences for endangered species. The order Nidovirales is currently classified into eight
Flies AS +7 more
europepmc +3 more sources