Results 91 to 100 of about 4,956,823 (296)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The association between shift work, shift work sleep disorders and premature ejaculation in male workers

BMC Public Health
Objective Shift work and Shift Work Sleep Disorder (SWSD) are known to affect the secretion of several neurotransmitters and hormones associated with premature ejaculation (PE).
Zhenming Zheng, Jiashan Pan, Zhimin Chen, Pan Gao, Jingjing Gao, Hui Jiang, Xiansheng Zhang   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Comparison the frequency of symptoms of acute shift work maladaption syndrome between two groups of shift workers

Salāmat-i kār-i Īrān, 2013
Background and aims: Shift work intolerance has symptoms that names shift work maladaption syndrome. The aim of this study is the comparison between frequency of symptoms of acute shift work maladaption syndrome in two groups of shift workers.   Methods:
Seyedeh Negar Assadi
doaj  

Working hour characteristics and schedules among nurses in three Nordic countries – a comparative study using payroll data

BMC Nursing, 2019
Background Organisation of working hour schedules in the Northern European countries are rather similar. EU countries are obliged to adopt national legislation regarding duration of weekly working hours and rest periods. Yet, working hour characteristics
Anne Helene Garde, Anette Harris, Øystein Vedaa, Bjørn Bjorvatn, Johnni Hansen, Åse Marie Hansen, Henrik A. Kolstad, Aki Koskinen, Ståle Pallesen, Annina Ropponen, Mikko I. Härmä   +10 more
doaj   +1 more source

Characterization for entropy of shifts of finite type on Cayley trees

, 2017
The notion of tree-shifts constitutes an intermediate class in between one-sided shift spaces and multidimensional ones. This paper proposes an algorithm for computing of the entropy of a tree-shift of finite type.
Ban, Jung-Chao, Chang, Chih-Hung
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Measuring, Predicting and Visualizing Short-Term Change in Word Representation and Usage in VKontakte Social Network

, 2017
Language in social media is extremely dynamic: new words emerge, trend and disappear, while the meaning of existing words can fluctuate over time. Such dynamics are especially notable during a period of crisis. This work addresses several important tasks
Arendt, Dustin, Bell, Eric, Stewart, Ian, Volkova, Svitlana   +3 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source