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Hemolytic uremic syndrome induced by lipopolysaccharide and Shiga-like toxin
Pediatric Nephrology, 2004Induction of experimental hemolytic uremic syndrome (HUS) by simply administering Shiga-like toxin (Stx) to rodents has not yet been successful. Attention has been paid to the role of lipopolysaccharide (LPS) in the pathogenesis of HUS. In this study, we showed successful induction of an experimental HUS in LPS responder mice by administering Stx ...
Masahiro, Ikeda +2 more
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Shiga-Like Toxins as Targeted Anticancer Agents
2002A large number of structurally related protein toxins are derived from bacterial and plant sources. They target specific cell types by virtue of their receptor-binding domains that typically recognize glycolipids or glycoproteins. Some of these toxins, such as ricin and abrin, are ribosome-inactivating proteins (or RIPs) defining them as cytotoxic ...
Paul LaPointe, Jean Gariépy
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Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3
The Journal of Infectious Diseases, 1992Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
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A Prospective Study of Shiga-Like Toxin-Associated Diarrhea in a Pediatric Population
Journal of Pediatric Gastroenterology and Nutrition, 1994SummaryAlthough population‐based studies have shown that children have the highest age‐specific incidence of infection with the Shiga‐like toxin‐producing E. coli (SLTEC), these sporadic case series were not focused specifically on the pediatric age group. We undertook a prospective study to determine the frequency of detection of SLT in an exclusively
R E, Bégué +3 more
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2011
Ricin, Shiga-like toxin 1 (Stx1) and Shiga-like toxin 2 (Stx2) are ribosome inactivating proteins (RIPs) that catalytically remove an adenine residue from the highly conserved α-sarcin/ricin loop (SRL) in the large ribosomal subunit, inhibiting the translocation step of protein synthesis.
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Ricin, Shiga-like toxin 1 (Stx1) and Shiga-like toxin 2 (Stx2) are ribosome inactivating proteins (RIPs) that catalytically remove an adenine residue from the highly conserved α-sarcin/ricin loop (SRL) in the large ribosomal subunit, inhibiting the translocation step of protein synthesis.
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Mode of Action of Shiga and Shiga-Like Toxins
1990Enterohemorrhagic Escherichia coli 0157:H7 and other serotypes produce at least two distinct cytotoxins that affect Vero cells (Vero toxins).9,14,15,17 Both Vero toxins have been purified to homogeneity and the properties of the purified toxins have been examined extensively.9,17 One of them was found to be identical to Shiga toxin in molecular ...
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Shiga and Shiga-Like Toxins: A Family of Related Cytotoxins
1987Shiga toxin is a potent cytotoxin produced by Shigella dysenteviae 1 that is also enterotoxic for ligated rabbit ileum and paralytic and lethal for mice and rabbits (1). Shiga toxin was first described in 1903 by Conradi (2), and it is the prototype toxin for a family of related toxins called Shiga-like toxins (SLT’s) or verotoxins.
A. D. O’Brien +8 more
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Vero Cytotoxins (Shiga-Like Toxins) of Escherichia coli
1991Shiga toxin produced by strains of Shigella dysenteriae type 1 and Vero cytotoxins (Shiga-like toxins) produced by strains of Escherichia coli belong to a family of related toxins. Two major forms of Vero cytotoxin (VT) are recognised. Polyclonal antiserum to Shiga toxin neutralises the activity of VT1 (SLTI) but not VT2 (SLTII). Strains of E.
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Structure-function analyses of Shiga toxin and the Shiga-like toxins
Microbial Pathogenesis, 1990openaire +2 more sources