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Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2
Nature Chemical Biology, 2020 The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic ...
Alison Forrester +19 more
openalex +3 more sources
The Effect of Mitomycin C on Induction of Shiga Toxin Production in Clinical STEC Isolates [PDF]
ToxinsEarly determination of the Shiga toxin type of Shiga toxin-producing Escherichia coli (STEC) is crucial for guiding STEC-infected patients for proper and timely treatment and patient care.
Surangi H. Thilakarathna +2 more
doaj +2 more sources
Treatment Strategies for Infections With Shiga Toxin-Producing Escherichia coli
Frontiers in Cellular and Infection Microbiology, 2020 Infections with Shiga toxin-producing Escherichia coli (STEC) cause outbreaks of severe diarrheal disease in children and the elderly around the world. The severe complications associated with toxin production and release range from bloody diarrhea and ...
Sabrina Mühlen +3 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Shiga toxin-producing Escherichia coli (STEC) is a global foodborne bacterial pathogen that is often accountable for colon disorder or distress. STEC commonly induces severe diarrhea in hosts but can cause critical illnesses due to the Shiga toxin ...
Su-bin Hwang +6 more
doaj +2 more sources
Emerging Infectious Diseases, 2017 During a large outbreak of Shiga toxin−producing Escherichia coli illness associated with an agricultural show in Australia, we used whole-genome sequencing to detect an IS1203v insertion in the Shiga toxin 2c subunit A gene of Shiga toxin−producing E ...
Bhakti R. Vasant +16 more
doaj +2 more sources
Microvesicle Involvement in Shiga Toxin-Associated Infection
Toxins, 2017 Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS).
Annie Villysson +2 more
doaj +2 more sources
MicroorganismsShiga toxin (Stx), the main virulence factor of Shiga-toxin-producing E. coli (STEC), was first discovered in Shigella dysenteriae strains. While several other bacterial species have since been reported to produce Stx, STEC poses the most significant ...
Xuan Wang +6 more
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Shiga Toxin—A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis
Toxins, 2017 The cellular entry of the bacterial Shiga toxin and the related verotoxins has been scrutinized in quite some detail. This is due to their importance as a threat to human health.
Ludger Johannes
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Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit. [PDF]
PLoS ONE, 2016 Infections with shiga toxin-producing bacteria, like enterohemorrhagic Escherichia coli and Shigella dysenteriae, represent a serious medical problem. No specific and effective treatment is available for patients with these infections, creating a need ...
Petra Zadravec +8 more
doaj +2 more sources
Toxins, 2022 Shiga toxin-producing Escherichia coli (STEC)-associated hemolytic uremic syndrome (STEC-HUS) is a clinical syndrome involving hemolytic anemia (with fragmented red blood cells), low levels of platelets in the blood (thrombocytopenia), and acute kidney ...
Yang Liu +4 more
semanticscholar +1 more source