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Mild Illness during Outbreak of Shiga Toxin−Producing Escherichia coli O157 Infections Associated with Agricultural Show, Australia

Emerging Infectious Diseases, 2017
During a large outbreak of Shiga toxin−producing Escherichia coli illness associated with an agricultural show in Australia, we used whole-genome sequencing to detect an IS1203v insertion in the Shiga toxin 2c subunit A gene of Shiga toxin−producing E ...
Bhakti R. Vasant, Russell J. Stafford, Amy V. Jennison, Sonya M. Bennett, Robert J. Bell, Christine J. Doyle, Jeannette R. Young, Susan A. Vlack, Paul Titmus, Debra El Saadi, Kari A.J. Jarvinen, Patricia Coward, Janine Barrett, Megan Staples, Rikki M.A. Graham, Helen V. Smith, Stephen B. Lambert   +16 more
doaj   +2 more sources

Shiga Toxin Therapeutics: Beyond Neutralization [PDF]

Toxins, 2017
Ribotoxic Shiga toxins are the primary cause of hemolytic uremic syndrome (HUS) in patients infected with Shiga toxin-producing enterohemorrhagic Escherichia coli (STEC), a pathogen class responsible for epidemic outbreaks of gastrointestinal disease around the globe.
Gregory Hall, Shinichiro Kurosawa, Deborah J. Stearns-Kurosawa   +2 more
openaire   +4 more sources

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

Frontiers in Cellular and Infection Microbiology, 2012
Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone, Cheleste eThorpe, Amrita eAhluwalia, Amrita eAhluwalia, Arlin eRogers, Fumiko eObata, Aimee eVozenilek, Glynis eKolling, Anne eKane, Bruce eMagun, Dakshina eJandhyala   +10 more
doaj   +1 more source

The pathogenic mechanisms of Shiga toxin and the Shiga‐like toxins [PDF]

Molecular Microbiology, 1991
SummaryIt is now well documented that some enteric bacteria which cause diarrhoeal and/or dysenteric disease produce, at high levels, one or more of a family of protein toxins referred to as Shiga toxin and Shiga‐like toxins (SLTs; alternatively called verocytotoxins or VTs).
V L, Tesh, A D, O'Brien
openaire   +2 more sources

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2013
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Imamovic, Lejla, Muniesa Pérez, Ma Teresa   +1 more
core   +2 more sources

Open-source genomic analysis of Shiga-toxin–producing E. coli O104:H4 [PDF]

, 2011
An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic
Antoine Danchin, Cordesmeyer S, Dongfang Li, Fei Pu, Feng Xi, George F. Gao, Holger Rohde, Huanming Yang, Itoh Y, Jian Wang, Jianguo Xu, Jun Oh, Jun Wang, Junhua Li, Junjie Qin, Kuijper E, Liang Yang, Mark J. Pallen, Martin Aepfelbacher, Martin Christner, Meiru Zhao, Moritz Hentschke, Nicholas J. Loman, Peng Wang, Robin Kobbe, Ruifu Yang, Scheutz F, Sebastian Loos, Shenghui Li, Wentong Chen, Xiangna Zhao, Xianwei Yang, Yajun Song, Yangqing Peng, Yin Li, Yingrui Li, Yuanlin Guan, Yujun Cui, Zhaoxi Zhang, Zhong Cen   +39 more
core   +1 more source

Shiga Toxin: Expression, Distribution, and Its Role in the Environment

Toxins, 2011
In this review, we highlight recent work that has increased our understanding of the production and distribution of Shiga toxin in the environment. Specifically, we review studies that offer an expanded view of environmental reservoirs for Shiga toxin ...
Steven A. Mauro, Gerald B. Koudelka
doaj   +1 more source

Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Amessou, Mohamed, Falguières, Thomas, Fradagrada, Alexandre, Johannes, Ludger, Lamaze, Christophe, Lord, Mike, Roberts, L. M. (Lynne M.), Smith, Daniel C.   +7 more
core   +1 more source

Down-Regulation of Renal Klotho Expression by Shiga Toxin 2

Kidney & Blood Pressure Research, 2014
Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate ...
Martina Feger, Sobuj Mia, Tatsiana Pakladok, Jan P. Nicolay, Ioana Alesutan, Stefan W. Schneider, Jakob Voelkl, Florian Lang   +7 more
doaj   +1 more source

Isolation of verotoxin-producing Escherichia coli associated with diarrhoea in Malaysia containing plasmids showing homology with biotinylated Shiga-like toxin DNA gene probes [PDF]

, 1996
Three strains of verotoxin-producing Escherichia coli isolated from patients with haemorrhagic colitis harboured plasmids ranging in size from 2.7 kb to 91.2 kb. Those plasmids ranging from 2.7 kb to 6.8 kb hybridized to Shiga-like toxin I and Shiga-like
Abdul Karim, Mohamed Ismail, Ansary, A., Radu, Son, Rahmat Ali, Gulam Rusul   +3 more
core   +1 more source