The Effect of Mitomycin C on Induction of Shiga Toxin Production in Clinical STEC Isolates [PDF]
ToxinsEarly determination of the Shiga toxin type of Shiga toxin-producing Escherichia coli (STEC) is crucial for guiding STEC-infected patients for proper and timely treatment and patient care.
Surangi H. Thilakarathna +2 more
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Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit. [PDF]
PLoS ONE, 2016 Infections with shiga toxin-producing bacteria, like enterohemorrhagic Escherichia coli and Shigella dysenteriae, represent a serious medical problem. No specific and effective treatment is available for patients with these infections, creating a need ...
Petra Zadravec +8 more
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A translational murine model of sub-lethal intoxication with Shiga toxin 2 reveals novel ultrastructural findings in the brain striatum. [PDF]
PLoS ONE, 2013 Infection by Shiga toxin-producing Escherichia coli causes hemorrhagic colitis, hemolytic uremic syndrome (HUS), acute renal failure, and also central nervous system complications in around 30% of the children affected. Besides, neurological deficits are
Carla Tironi-Farinati +5 more
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A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing E. coli and Other Bacterial Hosts [PDF]
MicroorganismsShiga toxin (Stx), the main virulence factor of Shiga-toxin-producing E. coli (STEC), was first discovered in Shigella dysenteriae strains. While several other bacterial species have since been reported to produce Stx, STEC poses the most significant ...
Xuan Wang +6 more
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Chemosensors, 2022 Foodborne bacteria have persisted as a significant threat to public health and to the food and agriculture industry. Due to the widespread impact of these pathogens, there has been a push for the development of strategies that can rapidly detect ...
Sabrina Petrucci +3 more
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Influence of temperature and pH on induction of Shiga toxin Stx1a in Escherichia coli
Frontiers in Microbiology, 2023 Shiga toxin-producing strains represent pathogenic group that is of concern in food production. The present study evaluated forty-eight E. coli isolates (11 with intact stx gene, while remaining isolates presented only stx-fragments) for Shiga toxin ...
Vinicius Silva Castro +2 more
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Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells. [PDF]
PLoS ONE, 2015 The heat shock protein 90 (Hsp90) inhibitor geldanamycin (GA) has been shown to alter endosomal sorting, diverting cargo destined for the recycling pathway into the lysosomal pathway. Here we investigated whether GA also affects the sorting of cargo into
Anne Berit Dyve Lingelem +4 more
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Shiga Toxin-Producing Escherichia coli: Detection, Differentiation, and Implications for Food Safety
EDIS, 2016 Shiga toxin is a protein found within the genome of a type of virus called a bacteriophage. These bacteriophages can integrate into the genomes of the bacterium E. Coli. Even though most E. coli are benign or even beneficial members of our gut microbial
William J. Zaragoza +2 more
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Serine protease EspP from enterohemorrhagic Escherichia coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium. [PDF]
PLoS ONE, 2013 Life-threatening intestinal and systemic effects of the Shiga toxins produced by enterohemorrhagic Escherichia coli (EHEC) require toxin uptake and transcytosis across intestinal epithelial cells.
Julie In +12 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2012 Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone +10 more
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