Results 91 to 100 of about 54,271 (248)

Development of a Synthetic Lethality‐Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer

Cancer Science, EarlyView.
This study identified LIG1 as a novel synthetic lethality‐inducing factor in prostate cancer through a genome‐wide CRISPR‐Cas9 knockout screen and demonstrated that its inhibition enhances the efficacy of PARP inhibitor. The combination of L82‐G17 and olaparib showed synergistic antitumor effects both in vitro and in vivo, offering a promising ...
Masaru Tani, Koji Hatano, Yu Ishizuya, Toshiki Oka, Tomohiro Kanaki, Shunsuke Inoguchi, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Sassi Nesrine, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Takao Yamaguchi, Satoshi Obika, Kosuke Yusa, Norio Nonomura, Keisuke Nimura   +22 more
wiley   +1 more source

Do the A Subunits Contribute to the Differences in the Toxicity of Shiga Toxin 1 and Shiga Toxin 2?

Toxins, 2015
Shiga toxin producing Escherichia coli O157:H7 (STEC) is one of the leading causes of food-poisoning around the world. Some STEC strains produce Shiga toxin 1 (Stx1) and/or Shiga toxin 2 (Stx2) or variants of either toxin, which are critical for the ...
Debaleena Basu, Nilgun E. Tumer
doaj   +1 more source

Microangiopathic Anemia without Thrombocytopenia and Kidney Disease in a Child with Diarrhea Caused by Shiga Toxin-Producing Escherichia coli [PDF]

, 2017
A child with a history of diarrhea presented with transient anemia, reticolucytosis, and red blood cell fragmentation. Blood pressure and levels of blood platelets, creatinine, and urea were normal, as were results of urinalysis.
Bianchetti, Mario G., Meier, Paul W., Pachlopnik, Jana M., Rudin, Christoph, von der Weid, Nicolas X.   +4 more
core  

Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience [PDF]

, 2014
The aim of this study was to identify the best practices for the detection of Shiga toxin-producing Escherichia coli (STEC) in children with diarrheal illness treated at a tertiary care center, i.e., sorbitol-MacConkey (SMAC) agar culture, enzyme ...
Burnham, Carey-Ann D, Schindler, Emily I, Sellenriek, Patricia, Storch, Gregory A, Tarr, Phillip I   +4 more
core   +2 more sources

Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen

The FEBS Journal, EarlyView.
We investigated the role of the signal regulatory protein alpha (SIRPα)/CD47 axis in phagocytosis by disrupting the SIRPA gene in the THP‐1 cell line. The SIRPα KO THP‐1 cells retained their monocyte and macrophage characteristics similar to their wild‐type (WT) counterparts.
Saitong Muneekaew, Pasut Sasithong, Koollawat Chupradit, Kritayaporn Saiprayong, Thunchanok Nuchphongsai, Methichit Wattanapanitch   +5 more
wiley   +1 more source

Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism. [PDF]

, 2019
Colonocytes possess a specific carrier-mediated uptake process for the microbiota-generated thiamin (vitamin B1) pyrophosphate (TPP) that involves the TPP transporter (TPPT; product of the SLC44A4 gene).
Anandam, Kasin Yadunandam, Sabui, Subrata, Said, Hamid M, Subramanian, Sreya, Thompson, Morgan M   +4 more
core   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, EarlyView.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Day-to-day dynamics of commensal Escherichia coli in Zimbabwean cows evidence temporal fluctuations within a host-specific population structure [PDF]

, 2017
To get insights into the temporal pattern of commensal Escherichia coli populations, we sampled the feces of four healthy cows from the same herd in the Hwange District of Zimbabwe daily over 25 days. The cows had not received antibiotic treatment during
Andremont, Antoine, Caron, Alexandre, Chatel, Jérémie, Clermont, Olivier, Couffignal, Camille, D'Humières, Camille, Denamur, Erick, Massot, Méril, Mentré, France, Plault, Nicolas   +9 more
core   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Characterization of Rabbit Polyclonal Sera against Recombinant Shiga Toxin and its Subunits for Detection of Stx-Producing E. coli

Iranian Journal of Allergy, Asthma and Immunology, 2011
Shiga toxin (Stx) is the principal virulence factor of Shigatoxigenic Escherichia coli (STEC), a food-born pathogen associated disease with uncomplicated diarrhea or the hemolytic-uremic syndrome.
Mana Oloomi, Saeid Bouzari
doaj