Mechanism of Shiga Toxin Clustering on Membranes
ACS Nano, 2016 The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells.
W. Pezeshkian +8 more
semanticscholar +1 more source
Toxins, 2010 Despite efforts to improve hygenic conditions and regulate food and drinking water safety, the enteric pathogens, Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae serotype 1 remain major public health concerns due to widespread ...
Moo-Seung Lee +2 more
doaj +1 more source
The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]
, 2006 Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, Thomas +7 more
core +3 more sources
Detection, Characterization, and Typing of Shiga Toxin-Producing Escherichia coli
Frontiers in Microbiology, 2016 Shiga toxin-producing Escherichia coli (STEC) are responsible for gastrointestinal diseases reported in numerous outbreaks around the world. Given the public health importance of STEC, effective detection, characterization and typing is critical to any ...
B. Parsons +3 more
semanticscholar +1 more source
Identification and detection of iha subtypes in LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains isolated from humans, cattle and food [PDF]
, 2019 LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains are important cause of infection in humans and they should be included in the public health surveillance systems.
Colello, Rocío +6 more
core +1 more source
Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation.
Soft Matter, 2016 The bacterial Shiga toxin is composed of an enzymatically active A-subunit, and a receptor-binding homopentameric B-subunit (STxB) that mediates intracellular toxin trafficking.
W. Pezeshkian +9 more
semanticscholar +1 more source
Biological Journal of Microorganism, 2013 Introduction: Pathogens can be transmitted to the humans through the consumption of contaminated meat and thus causing disease. Shiga-toxin-producing Escherichia coli can cause mild watery diarrhea to more serious complications of hemorrhagic colitis ...
Marzieh Tadi Beni +7 more
doaj
Frontiers in Microbiology, 2016 Similar to ruminants, swine have been shown to be a reservoir for Shiga toxin-producing Escherichia coli (STEC), and pork products have been linked with outbreaks associated with STEC O157 and O111:H-.
G. Baranzoni +9 more
semanticscholar +1 more source
Consensus report: E. coli O104:H4 (HUSEC041) and the potential threat to European water supplies. [PDF]
, 2011 Among the 3rd Seminar for PhD students working on Water and Health which was held in Cannes on 27–29 June 2011, experts from a number of universities and research institutes took the opportunity to discuss the emergence of Escherichia coli O104:H4 in ...
Exner, Martin +7 more
core
Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience [PDF]
, 2014 The aim of this study was to identify the best practices for the detection of Shiga toxin-producing Escherichia coli (STEC) in children with diarrheal illness treated at a tertiary care center, i.e., sorbitol-MacConkey (SMAC) agar culture, enzyme ...
Burnham, Carey-Ann D +4 more
core +2 more sources