Results 201 to 210 of about 366,512 (248)

Shiga toxin-induced haemolytic uraemic syndrome and the role of antibiotics: a global overview.

Journal of Infection, 2019
OBJECTIVES The administration of antibiotics in infections caused by Shiga toxin producing E. coli (STEC) strains, such as O157:H7, was and remains controversial, as it has been associated with the development of haemolytic uraemic syndrome (HUS).
L. Kakoullis, E. Papachristodoulou, Paraskevi Chra, G. Panos   +3 more
semanticscholar   +1 more source

Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

Microbes and Infection, 2001
Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.
E V, O'Loughlin, R M, Robins-Browne
openaire   +2 more sources

Shiga toxins

Toxicon, 2001
Shiga toxin and Shiga-like toxins belong to the group of protein toxins which have a moiety that binds to the cell surface and another enzymatically active moiety that after entry into the cytosol inhibits protein synthesis enzymatically. The toxins can also cause apoptosis by mechanisms that may be different from the effect on the protein synthesis ...
openaire   +2 more sources

Shiga Toxin 1a Blunts Shiga Toxin 2a-pathogenic Effects in Blood

Thrombosis and Haemostasis
Background Once released into human blood, Shiga toxins (Stx) interact with platelets and leukocytes, stimulating them to form aggregates and to release pathogenic extracellular vesicles (EV) containing Stx.
E. Varrone, L. Consagra, G. Rossi, D. Carnicelli, Paola Paterini, Barbara Brunetti, Francesca Ricci, P. Tazzari, G. Storci, Massimiliano Bonafé, G. Ardissino, M. Brigotti   +11 more
semanticscholar   +1 more source

Shiga Toxin Producing Escherichia coli

Clinics in Laboratory Medicine, 2015
Shiga toxin-producing Escherichia coli (STEC) is among the common causes of foodborne gastroenteritis. STEC is defined by the production of specific toxins, but within this pathotype there is a diverse group of organisms. This diversity has important consequences for understanding the pathogenesis of the organism, as well as for selecting the optimum ...
Allen, Bryan, Ilan, Youngster, Alexander J, McAdam   +2 more
openaire   +2 more sources

Shiga toxin-producing Escherichia coli

Current Infectious Disease Reports, 1999
Shiga toxin-producing Escherichia coli (STEC) are emerging as a significant source of foodborne infectious disease in the developed world. Multistate outbreaks of E. coli O157 and non-O157 serogroups in the United States are facilitated by the centralization of food processing and distribution.
, Jaeger, , Acheson
openaire   +2 more sources

Protection of Monkeys against Shiga Toxin Induced by Shiga Toxin-Liposome Conjugates

International Archives of Allergy and Immunology, 2002
<i>Background:</i> We previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against ...
Yuriko, Suzaki, Yasushi, Ami, Noriyo, Nagata, Seishiro, Naito, Hiroshi, Kato, Maiko, Taneichi, Motohide, Takahashi, Takako, Komiya, Sachihiro, Satoh, Fumio, Gondaira, Junichi, Sugiyama, Yoshio, Nakano, Masahito, Mori, Katsutoshi, Komuro, Tetsuya, Uchida   +14 more
openaire   +2 more sources

Shiga-toxin-converting bacteriophages

Research in Microbiology, 2001
Shiga toxins (Stx) comprise a family of potent cytotoxins that are involved in severe human disease. Stx are mainly produced by Escherichia coli isolated from human and nonhuman sources, and by Shigella dysenteriae type 1. The genes encoding Stx are thought to be generally encoded in the genome of lambdoid prophages (Stx-converting bacteriophages; Stx ...
openaire   +2 more sources

Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3

The Journal of Infectious Diseases, 1992
Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
openaire   +2 more sources

Shiga Toxin-Producing Escherichia coli

2014
In the United States, it is estimated that non-O157 Shiga toxin-producing Escherichia coli (STEC) cause more illnesses than STEC O157:H7, and the majority of cases of non-O157 STEC infections are due to serogroups O26, O45, O103, O111, O121, and O145, referred to as the top six non-O157 STEC.
James L, Smith, Pina M, Fratamico, Nereus W, Gunther   +2 more
openaire   +2 more sources