Presence of activatable Shiga toxin genotype (stx2d) in Shiga toxigenic Escherichia coli from livestock sources [PDF]
, 2003 Stx2d is a recently described Shiga toxin whose cytotoxicity is activated 10- to 1,000-fold by the elastase present in mouse or human intestinal mucus. We examined Shiga toxigenic Escherichia coli (STEC) strains isolated from food and livestock sources ...
Doi:j. Clin Microbiol +7 more
core +3 more sources
Shiga Toxin 2 Targets the Murine Renal Collecting Duct Epithelium [PDF]
Infection and Immunity, 2009 ABSTRACTHemolytic-uremic syndrome (HUS) caused by Shiga toxin-producingEscherichia coliinfection is a leading cause of pediatric acute renal failure. Bacterial toxins produced in the gut enter the circulation and cause a systemic toxemia and targeted cell damage. It had been previously shown that injection of Shiga toxin 2 (Stx2) and lipopolysaccharide
Psotka, MA +7 more
openaire +4 more sources
Shiga toxin-producing Escherichia coli O157:H7 in milk and milk products in Ogun State, Nigeria [PDF]
Veterinaria Italiana, 2014 Shiga toxin producing Escherichia coli (STEC) O157 is a major cause of food-borne illnesses in humans. This study investigated the presence of STEC O157 in milk and milk products in Ogun State, Nigeria. Of a total of 202 samples 10 (5%) were positive for
Akhigbe Ivbade +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Shiga toxin is the main virulence factor of non-invasive enterohemorrhagic Escherichia coli strains capable of causing hemolytic uremic syndrome. Our group has previously shown that the toxin can reach the kidney within microvesicles where it is taken up
Karl Johansson +6 more
doaj +1 more source
Scientific Reports, 2021 Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of intestinal pathogens responsible for a range of illnesses, including kidney failure and neurological compromise.
Patricia B. Lodato
doaj +1 more source
Identification and detection of iha subtypes in LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains isolated from humans, cattle and food [PDF]
, 2019 LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains are important cause of infection in humans and they should be included in the public health surveillance systems.
Colello, Rocío +6 more
core +1 more source
The Effect of Mitomycin C on Induction of Shiga Toxin Production in Clinical STEC Isolates
ToxinsEarly determination of the Shiga toxin type of Shiga toxin-producing Escherichia coli (STEC) is crucial for guiding STEC-infected patients for proper and timely treatment and patient care.
Surangi H. Thilakarathna +2 more
doaj +1 more source
Associating sporadic, foodborne illness caused by Shiga toxin-producing Escherichia coli with specific foods : a systematic review and meta-analysis of case-control studies [PDF]
, 2019 Shiga toxin-producing Escherichia coli (STEC) infections are a significant public health issue, with foodborne transmission causing >1 million illnesses worldwide each year.
A. Gill +5 more
core +1 more source
Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2
Nature Chemical Biology, 2020 The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by which this is achieved remain unknown.
Forrester, Alison +19 more
openaire +4 more sources
Insight into Shiga toxin genes encoded by Escherichia coli O157 from whole genome sequencing [PDF]
, 2015 The ability of Shiga toxin-producing Escherichia coli (STEC) to cause severe illness in humans is determined by multiple host factors and bacterial characteristics, including Shiga toxin (Stx) subtype.
Asadulghani +21 more
core +2 more sources