Results 181 to 190 of about 20,091 (215)

Shiga toxins

Toxicon, 2012
Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain strains of Escherichia coli. There is currently no available treatment for disease caused by these toxin-producing bacteria, and understanding the biology of the Shiga toxins might be instrumental in addressing this issue.
Jonas Bergan, Anne Berit Dyve Lingelem, Roger Simm   +2 more
exaly   +3 more sources

Shiga toxins

Toxicon, 2001
Shiga toxin and Shiga-like toxins belong to the group of protein toxins which have a moiety that binds to the cell surface and another enzymatically active moiety that after entry into the cytosol inhibits protein synthesis enzymatically. The toxins can also cause apoptosis by mechanisms that may be different from the effect on the protein synthesis ...
Kirsten Sandvig
exaly   +3 more sources

Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

Microbes and Infection, 2001
Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.
E V O'Loughlin, Roy M Robins-Browne
exaly   +3 more sources

Entry of Shiga Toxin into Cells

Zentralblatt für Bakteriologie, 1993
The effect of Shiga toxin with mutations in the A fragment has been tested on cells in order to get more information about the processing of the A fragment during entry into the cytosol. A mutant with a deletion between the A1 and A2 domain in the A fragment is resistant to cleavage by trypsin and is less toxic than wild type toxin on both Vero and ...
Sandvig, Kirsten, Dubinina, Elena, Garred, Øystein, Prydz, Kristian, Kozlov, Juri V., Hansen, Steen H., van Deurs, Bo   +6 more
openaire   +2 more sources

Protection of Monkeys against Shiga Toxin Induced by Shiga Toxin-Liposome Conjugates

International Archives of Allergy and Immunology, 2002
<i>Background:</i> We previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against ...
Yuriko, Suzaki, Yasushi, Ami, Noriyo, Nagata, Seishiro, Naito, Hiroshi, Kato, Maiko, Taneichi, Motohide, Takahashi, Takako, Komiya, Sachihiro, Satoh, Fumio, Gondaira, Junichi, Sugiyama, Yoshio, Nakano, Masahito, Mori, Katsutoshi, Komuro, Tetsuya, Uchida   +14 more
openaire   +2 more sources

The Shiga toxin genotype rather than the amount of Shiga toxin or the cytotoxicity of Shiga toxin in vitro correlates with the appearance of the hemolytic uremic syndrome

Diagnostic Microbiology and Infectious Disease, 2007
Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and ...
Dorothea, Orth, Katharina, Grif, Abdul B, Khan, Asma, Naim, Manfred P, Dierich, Reinhard, Würzner   +5 more
openaire   +2 more sources

Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3

The Journal of Infectious Diseases, 1992
Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
openaire   +2 more sources

Shiga-toxin-converting bacteriophages

Research in Microbiology, 2001
Shiga toxins (Stx) comprise a family of potent cytotoxins that are involved in severe human disease. Stx are mainly produced by Escherichia coli isolated from human and nonhuman sources, and by Shigella dysenteriae type 1. The genes encoding Stx are thought to be generally encoded in the genome of lambdoid prophages (Stx-converting bacteriophages; Stx ...
openaire   +2 more sources

Affinity purification of Shiga-like toxin I and Shiga-like toxin II

Journal of Microbiological Methods, 1998
Abstract A facile method is described for affinity purifying Shiga-like toxin I (verotoxin 1) or Shiga-like toxin II (verotoxin 2) from cell-free Escherichia coli culture supernatant solutions using immobilized synthetic analogs of the digalactoside [αGal(1,4)βGal] host cell receptor for these toxins.
George Mulvey, Rosa Vanmaele, Monique Mrazek, Mark Cahill, Glen D. Armstrong   +4 more
openaire   +1 more source

Shiga Toxin: Purification, Structure, and Function

Clinical Infectious Diseases, 1991
Shiga toxin is a potent toxin produced by Shigella dysenteriae type 1 strains. The toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. It consists of two polypeptide chains, an A chain (molecular weight, 32,225) and a B chain (molecular weight, 7,691 ...
A, Donohue-Rolfe, D W, Acheson, G T, Keusch   +2 more
openaire   +2 more sources