Results 81 to 90 of about 19,735 (216)
Microbiology and Immunology, EarlyView.ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa +6 more
wiley +1 more source
Revisiting the STEC Testing Approach: Using espK and espV to Make Enterohemorrhagic Escherichia coli (EHEC) Detection More Reliable in Beef [PDF]
, 2016 Current methods for screening Enterohemorrhagic Escherichia coli (EHEC) O157 and non-O157 in beef enrichments typically rely on the molecular detection of stx, eae, and serogroup-specific wzx or wzy gene fragments.
Beutin, Lothar +7 more
core +3 more sources
The FEBS Journal, EarlyView.Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito +8 more
wiley +1 more source
Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli
Frontiers in Microbiology, 2017 Shiga-like toxin-producing Escherichia coli (STEC) O157:H7 poses grave challenges to public health by its ability to cause severe colonic diseases and renal failure in both human and animals.
Yong Zhang +11 more
doaj +1 more source
A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]
, 2016 Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian +12 more
core +2 more sources
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, EarlyView.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
THE USE OF MASS SPECTROMETRIC ANALYSIS FOR THE DETECTION OF BACTERIAL TOXINS
Журнал микробиологии, эпидемиологии и иммунобиологии, 2018 Toxins - molecular weight compounds produced by microorganisms, animals, plants and possessing antigene properties. Recently due to the perceived threat of terrorist actions identification of a number of bacterial toxins is especially important.
M. V. Poleeva, O. S. Chemisova
doaj +1 more source
Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]
, 2014 Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies +6 more
core +4 more sources
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova +2 more
wiley +1 more source
Bacterial Toxins: Friends or Foes?
Emerging Infectious Diseases, 1999 Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes.
Clare K. Schmitt +2 more
doaj +1 more source