Results 101 to 110 of about 130,160 (165)
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Contribution and interaction of Shiga toxin genes to Escherichia coli O157:H7 virulence [PDF]
, 2019 Escherichia coli O157:H7 is the predominant cause of diarrhea-associated hemolytic uremic syndrome (HUS) worldwide. Its cardinal virulence traits are Shiga toxins, which are encoded by stx genes, the most common of which are stx1a, stx2a, and stx2c.
Chui, Linda +15 more
core +1 more source
Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
The FEBS Journal, EarlyView.PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe +6 more
wiley +1 more source
Plasmonic Metasurfaces for Specific SERS Detection of Shiga Toxins. [PDF]
ACS Appl Mater Interfaces, 2022 Rippa M +13 more
europepmc +1 more source
Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment
The FEBS Journal, EarlyView.Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro +13 more
wiley +1 more source
Toxins in Fermented Foods: Prevalence and Preventions—A Mini Review
Toxins, 2018 Fermented foods (FF) are widely consumed around the world, and FF are one of the prime sources of toxins and pathogenic microbes that are associated with several foodborne outbreaks.
Bhagavathi Sundaram Sivamaruthi +2 more
doaj +1 more source
Journal of Applied Toxicology, Volume 46, Issue 11, Page 4144-4159, November 2026.ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li +10 more
wiley +1 more source
Escherichia coli Shiga Toxins and Gut Microbiota Interactions. [PDF]
Toxins (Basel), 2021 Lee KS, Jeong YJ, Lee MS.
europepmc +1 more source
Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.In a 12‐year‐old Pembroke Welsh Corgi, hepatocellular carcinoma was associated with left medial liver lobe torsion, with the torsion axis located at the base of the mass rather than at the hepatic hilus. Computed tomography revealed a whirl sign at this atypical site, enabling preoperative diagnosis and surgical planning.
Hitomi Shinoda +4 more
wiley +1 more source
A Macroporous Magnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III Secretory Proteins in Enterohemorrhagic Escherichia coli, Which Attenuates Virulence. [PDF]
Front Microbiol, 2022 Hirakawa H +5 more
europepmc +1 more source