Results 101 to 110 of about 20,091 (215)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Adenovirus vector expressing Stx1/Stx2-neutralizing agent protects piglets infected with Escherichia coli O157: H7 against fatal systemic intoxication [PDF]

, 2015
Hemolytic-uremic syndrome (HUS), caused by Shiga toxin (Stx)-producing Escherichia coli (STEC), remains untreatable. Production of human monoclonal antibodies against Stx, which are highly effective in preventing Stx sequelae in animal models, is ...
Beamer, Gillian, Cohen, Ocean, Curiel, David T, Debatis, Michelle, Dmitriev, Igor P, Kashentseva, Elena A, Mukherjee, Jean, Schearer, Jonathan, Sheoran, Abhineet S, Shoemaker, Charles B, Tremblay, Jacqueline M, Tzipori, Saul   +11 more
core   +2 more sources

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +4 more sources

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

UV-Sensitivity of Shiga Toxin-Converting Bacteriophage Virions Φ24B, 933W, P22, P27 and P32

Toxins, 2015
Shiga toxin-converting bacteriophages (Stx phages) are present as prophages in Shiga toxin-producing Escherichia coli (STEC) strains. Theses phages can be transmitted to previously non-pathogenic E.
Sylwia Bloch, Bożena Nejman-Faleńczyk, Gracja Topka, Aleksandra Dydecka, Katarzyna Licznerska, Magdalena Narajczyk, Agnieszka Necel, Alicja Węgrzyn, Grzegorz Węgrzyn   +8 more
doaj   +1 more source

A toxin hunter in the microworld of bacteria: a project on novel inhibitors against bacterial AB5 toxins [PDF]

, 2016
[要旨] 病原性細菌が産生する蛋白性のAB5型トキシンは1個のAサブユニットと5個のBサブユニットから構成される外毒素である。両サブユニットはそれぞれ特徴的な役割を持ち，互いに巧妙に機能分担をして一つのトキシンを形成している。Aサブユニットは主に毒性に直接関与する特異的な酵素活性を有する。一方，Bサブユニットは標的細胞のレセプターに対する結合能を有し，AB5型トキシンを標的細胞に吸着させる。ここでは毒性が全く異なるAB5型トキシンとして，コレラ菌が産生するコレラトキシン（CT ...
Fujun Shen (314092), Jiandong Yang (196004), Rong Hou (149003), Yang Da (89805)   +3 more
core   +3 more sources

Advances in High‐Throughput Sequencing: Antimicrobial Resistance and Traceability of Foodborne Pathogens

eFood, Volume 7, Issue 3, June 2026.
In this graphical abstract, the transfer experiment of antimicrobial resistance genes and metagenomic analysis are presented, and they are the core components of relevant microbial research. ABSTRACT High‐throughput sequencing technology (HTST) can effectively analyze the sequence information in the DNA of samples and provide a comprehensive ...
Kexuan Wu, Jie Zhao, Ningxin Huang, Zhengxiao Wang, Yiping Xu, Shaoning Liu, Chuanlin Bi, Juan Tang, Wei Wu   +8 more
wiley   +1 more source

Emerging Dissemination of blaCTX‐M‐65 in Bovine E. coli in Spain Associated With IncHI2 Plasmids

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The resistome in ESBL/AmpC‐producing E. coli in livestock was diverse and dominated by plasmid‐borne genes Detection of host‐independent dissemination of AMR determinants mediated by shared plasmid types First report in Spanish cattle of blaCTX‐M‐65 on IncHI2 plasmids, an under‐reported ESBL in Europe Identification of potentially zoonotic clones in ...
Medelin Ocejo, Beatriz Oporto, Ana Hurtado   +2 more
wiley   +1 more source

Presence of activatable Shiga toxin genotype (stx2d) in Shiga toxigenic Escherichia coli from livestock sources [PDF]

, 2003
Stx2d is a recently described Shiga toxin whose cytotoxicity is activated 10- to 1,000-fold by the elastase present in mouse or human intestinal mucus. We examined Shiga toxigenic Escherichia coli (STEC) strains isolated from food and livestock sources ...
Doi:j. Clin Microbiol, Kari S. Gobius, Glen M. Higgs, Patricia M, In Shiga Toxigenic Dstxgenotype, Kari S. Gobius, Glen M. Higgs, Patricia M. Desmarchelier   +7 more
core   +3 more sources