Results 111 to 120 of about 9,827 (181)

The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias

Cancer Science, Volume 117, Issue 8, Page 2274-2288, August 2026.
Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Ken Suzaki, Susumu Goyama, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda   +11 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, Volume 293, Issue 16, Page 4841-4859, August 2026.
Pyridoxal 5'‐phosphate (PLP), the coenzyme form of vitamin B6, is essential for amino acid metabolism. In mammals, PLP homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and ...
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Validation of a Cell-Based Assay for Detection of Active Shiga Toxins Produced by Escherichia coli in Water. [PDF]

Int J Environ Res Public Health, 2020
Hughes AC, Patfield S, Rasooly R, He X.
europepmc   +1 more source

Role of Shiga Toxins in Cytotoxicity and Immunomodulatory Effects of Escherichia coli O157:H7 during Host-Bacterial Interactions in vitro. [PDF]

Toxins (Basel), 2020
Bruballa AC, Shiromizu CM, Bernal AM, Pineda GE, Sabbione F, Trevani AS, Bentancor LV, Ramos MV, Fernández-Brando RJ, Muñoz MJ, Palermo MS.   +10 more
europepmc   +1 more source

Shiga Toxin [PDF]

, 2020
openaire   +1 more source

Use of Gb₃ trisaccharides with oligo-EG linker for the detection of Escherichia coli O157:H7 Shiga toxins present in a fresh vegetable salad. [PDF]

Anal Bioanal Chem
Uzawa H, Tanaka D, Oba Y, Seto Y, Nishida Y.   +4 more
europepmc   +1 more source

Diagnostic oriented discrimination of different Shiga toxins via PCA-assisted SERS-based plasmonic metasurface. [PDF]

Nanophotonics
Rippa M, Milano A, Marchesano V, Sagnelli D, Guilcapi B, D'Avino A, Palermo G, Strangi G, Consagra L, Brigotti M, Morabito S, Zyss J, Petti L.   +12 more
europepmc   +1 more source

Synthesis of biologically active Shiga toxins in cell-free systems. [PDF]

Sci Rep
Ramm F, Kaser D, König I, Fellendorf J, Wenzel D, Zemella A, Papatheodorou P, Barth H, Schmidt H.   +8 more
europepmc   +1 more source

Age related differences in phylogenetic diversity, prevalence of Shiga toxins, Intimin, Hemolysin genes and select serogroups of Escherichia. coli from pastured meat goats detected in a longitudinal cohort study. [PDF]

BMC Vet Res, 2020
Ndegwa E, Alahmde A, Kim C, Kaseloo P, O'Brien D.   +4 more
europepmc   +1 more source

Shiga Toxins Produced by Enterohaemorrhagic Escherichia coli Induce Inflammation in Toxin-Sensitive Cells through the p38 MAPK/MK2/Tristetraprolin Signaling Pathway. [PDF]

J Microbiol Biotechnol
Park SY, Jeong YJ, Lee KS, Park JY, Park J, Tesh VL, Lee MS.   +6 more
europepmc   +1 more source