Results 121 to 130 of about 20,091 (215)

Functionalized Diaryliodonium Salts with N‐Reactive Amides: Versatile Reactivity for Constructing Benzo‐Fused Nitrogen Heterocycles

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
A practical one‐pot strategy for the synthesis of ortho‐amide‐functionalized TMP‐iodonium(III) salts has been developed. These iodonium salts exhibited distinct reactivities toward N‐, O‐, and S‐nucleophiles, facilitating arylocyclization and producing a variety of benzo‐fused heterocycles under mild conditions.
Naoki Miyamoto   +4 more
wiley   +1 more source

Shiga Toxin 1a Blunts Shiga Toxin 2a-pathogenic Effects in Blood

open access: yesThrombosis and Haemostasis
ABSTRACT Once released into human blood, Shiga toxins (Stx) interact with platelets and leukocytes, stimulating them to form aggregates and to release pathogenic extracellular vesicles (EV) containing Stx. These EV are considered the trigger driving the transition from bloody diarrhea to the life-threatening hemolytic uremic syndrome (
Elisa, Varrone   +11 more
openaire   +2 more sources

STUDIES ON THE TOXIN PRODUCTION OF THE SHIGA BACILLI [PDF]

open access: yesJournal of Experimental Medicine, 1936
1. The S, R, and Rn variants of the Shiga bacillus are equally toxic. 2. The effect of the toxin upon rabbits is the same, whether it is derived from filtrates of broth cultures (3 to 6 days old), or is obtained by autolysis of the killed bacteria, grown on agar surface.
openaire   +2 more sources

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo   +10 more
wiley   +1 more source

Toxins in Fermented Foods: Prevalence and Preventions—A Mini Review

open access: yesToxins, 2018
Fermented foods (FF) are widely consumed around the world, and FF are one of the prime sources of toxins and pathogenic microbes that are associated with several foodborne outbreaks.
Bhagavathi Sundaram Sivamaruthi   +2 more
doaj   +1 more source

Shiga toxin 2 translocation across intestinal epithelium is linked to virulence of Shiga toxin-producing Escherichia coli in humans [PDF]

open access: yes, 2018
Shiga toxin-producing Escherichia coli (STEC) are characterized by the release of potent Shiga toxins (Stx), which are associated with severe intestinal and renal disease.
Beltrametti   +7 more
core   +2 more sources

Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment

open access: yesJournal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi   +7 more
wiley   +1 more source

Flagellin induces β-defensin 2 in human colonic ex vivo infection with enterohemorrhagic Escherichia coli [PDF]

open access: yes, 2016
Enterohemorrhagic E. coli (EHEC) is an important foodborne pathogen in the developed world and can cause life-threatening disease particularly in children.
Chan, Simon   +6 more
core   +1 more source

Role of ZNF652 in Regulating Hepatocellular Carcinoma Cell Proliferation and Apoptosis via the circRHOT1/SLC38A6 Axis

open access: yesThe Kaohsiung Journal of Medical Sciences, Volume 42, Issue 5, May 2026.
ABSTRACT Hepatocellular carcinoma (HCC) is a heterogeneous malignancy characterized by high mortality rates. This article presents a discussion of the role of ZNF652 in HCC cell proliferation and apoptosis, thereby identifying a new target for HCC treatment. The expression levels of ZNF652, circRHOT1, and SLC38A6 in HCC and healthy cells were analyzed.
Kang Chen   +7 more
wiley   +1 more source

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