Results 141 to 150 of about 9,721 (166)
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Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3
The Journal of Infectious Diseases, 1992Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
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Antibodies to Shiga toxins in Brazilian cattle
Toxicon, 2017Cattle are considered a reservoir of Shiga toxin-producing Escherichia coli (STEC). There is no information about the presence of antibodies against Shiga toxins in Brazilian bovine serum. Using ELISA, all sera tested showed antibodies against the two main STEC virulence factors; Stx1 and Stx2.
Bruno B, Yamamoto +6 more
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Effect of Shiga toxins on granulocyte function
Microbial Pathogenesis, 2002We already showed that injection of Shiga toxin (Stx) 2 into mice caused severe granulocytosis in the peripheral blood. In this study we further clarified changes of granulocyte function by Stx 2. The activity of medullasin, a neutral serine protease in granulocytes that injures endothelial cells in vessels, significantly increased when Stx 2 was ...
Yosuke, Aoki, Tac, Takeda
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Affinity purification of Shiga-like toxin I and Shiga-like toxin II
Journal of Microbiological Methods, 1998Abstract A facile method is described for affinity purifying Shiga-like toxin I (verotoxin 1) or Shiga-like toxin II (verotoxin 2) from cell-free Escherichia coli culture supernatant solutions using immobilized synthetic analogs of the digalactoside [αGal(1,4)βGal] host cell receptor for these toxins.
George Mulvey +4 more
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Shiga Toxin: Purification, Structure, and Function
Clinical Infectious Diseases, 1991Shiga toxin is a potent toxin produced by Shigella dysenteriae type 1 strains. The toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. It consists of two polypeptide chains, an A chain (molecular weight, 32,225) and a B chain (molecular weight, 7,691 ...
A, Donohue-Rolfe +2 more
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2000
Abstract Shigellosis in children (rarely in adults) is often associated with lethargy, seizures, and headache; shiga toxin, produced by strains of Shigella dysenteriae type 1, has been considered responsible for these effects (1). Shiga toxin is a representative of a larger family of toxins (verotoxins) produced by ...
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Abstract Shigellosis in children (rarely in adults) is often associated with lethargy, seizures, and headache; shiga toxin, produced by strains of Shigella dysenteriae type 1, has been considered responsible for these effects (1). Shiga toxin is a representative of a larger family of toxins (verotoxins) produced by ...
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Detection Methods for Shiga Toxins and Shiga Toxin-Producing E. coli
2017Shiga toxin detection methods reflect the complicated biological processes that deliver these toxins to their target cells. Some detection methods employ techniques that indirectly detect the presence of Shiga toxins. Microbiological methods are used to identify pathogenic serotypes of E. coli, such as the infamous O157:H7, but the potential production
Christopher J. Silva +3 more
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Inhibition Of Shiga-Like Toxins By Brefeldin A
Journal of Infectious Diseases, 1995The effects of Shiga-like toxins on the morphology and protein synthetic capability of HeLa cells in tissue culture could be prevented by brefeldin A, an inhibitor of certain intracellular Golgi functions. Brefeldin A was without effect on the binding of Shiga-like toxin to cells.
S T, Donta +2 more
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Phage display and Shiga toxin neutralizers
Toxicon, 2016The current work presents an overview of the use of phage display technology for the identification and characterization of potential neutralizing agents for Shiga toxins. The last major Shiga toxin-associated disease outbreak, which took place in Germany in 2011, showed the international community that Shiga toxins remain a serious threat to public ...
Robert Alvin, Bernedo-Navarro +1 more
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Interaction of Shiga Toxin with Endothelial Cells
2003Item does not contain ...
Bitzan, M., Loo, D.M.W.M. te
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