Results 101 to 110 of about 54,989 (228)

Stable Chromosomal Expression of Shigella flexneri 2a and 3a O-Antigens in the Live Salmonella Oral Vaccine Vector Ty21a

open access: yesClinical and Vaccine Immunology, 2017
We have been exploring the use of the live attenuated Salmonella enterica serovar Typhi Ty21a vaccine strain as a versatile oral vaccine vector for the expression and delivery of multiple foreign antigens, including Shigella O-antigens. In this study, we
Madushini N. Dharmasena   +4 more
semanticscholar   +1 more source

Epidemiological Characteristics, Antibiotic Resistance Patterns and Genomic Analysis of Shigella Isolated in Pudong, Shanghai During 2013–2024

open access: yesAntibiotics
Background: Shigella spp. are critical pathogens causing diarrheal diseases. This study analyzed the epidemiological characteristics, antimicrobial resistance profiles, virulence factor profiles, and molecular patterns of Shigella isolates in Pudong New ...
Yue Zhang   +10 more
doaj   +1 more source

Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study

open access: yesClinical and Vaccine Immunology, 2016
Several candidate vaccines against Shigella spp. are in development, but the lack of a clear correlate of protection from challenge with the induction of adequate immune responses among the youngest age groups in the developing world has hampered ...
M. Riddle   +12 more
semanticscholar   +1 more source

Characterization and Genomic Study of the Novel Bacteriophage HY01 Infecting Both Escherichia coli O157:H7 and Shigella flexneri: Potential as a Biocontrol Agent in Food

open access: yesPLoS ONE, 2016
Background Escherichia coli O157:H7 and Shigella flexneri are well-known food-borne pathogens causing severe food poisoning at low infectious doses. Bacteriophages have been approved for food applications by the US Food and Drug Administration (FDA) and ...
Heyn Lee   +6 more
semanticscholar   +1 more source

Shigella flexneri suppresses NF-kB activation by inhibiting linear ubiquitin chain ligation

open access: yesNature Microbiology, 2016
The linear ubiquitin chain assembly complex (LUBAC) is a multimeric E3 ligase that catalyses M1 or linear ubiquitination of activated immune receptor signalling complexes (RSCs).
Maarten De Jong   +3 more
semanticscholar   +1 more source

Molecular and Cellular Mechanisms of Shigella flexneri Dissemination

open access: yesFrontiers in Cellular and Infection Microbiology, 2016
The intracellular pathogen Shigella flexneri is the causative agent of bacillary dysentery in humans. The disease is characterized by bacterial invasion of intestinal cells, dissemination within the colonic epithelium through direct spread from cell to ...
H. Agaisse
semanticscholar   +1 more source

Epithelzellinvasion durch Shigella flexneri

open access: yes, 2002
Shigellen sind Erreger der bakteriellen Dysenterie beim Menschen. Ein notwendiger Schritt bei der Pathogenese der Shigellose ist die Invasion von Darmepithelzellen durch das Bakterium. Der Mikroorganismus löst dabei in der Wirtszelle Veränderungen des Aktinzytoskeletts aus, die zur Bildung einer blütenähnlichen Membranstruktur und schließlich zur ...
openaire   +1 more source

Development of a Novel Shigella Quadrivalent Conjugate Vaccine Using Shigella O-Polysaccharide and IpaB Carrier Protein

open access: yesVaccines
Background/Objectives: Shigella is the leading bacterial cause of diarrheal disease worldwide. Although multiple vaccine candidates are under development and in clinical trials, no Shigella vaccine is currently available on the market. Shigella comprises
Shangdong Guo   +19 more
doaj   +1 more source

Aktivitas Antibakteri Infusa Daun Dandang Gendis (Clinacanthus nutans (Burm.f.) Lindau) Terhadap Pertumbuhan Shigella flexneri

open access: yesMajalah Kedokteran Andalas
Tujuan: Mengetahui aktivitas antibakteri infusa daun dandang gendis terhadap pertumbuhan Shigella flexneri dan mengetahui konsentrasi efektif infusa daun dandang gendis pada pertumbuhan Shigella flexneri; Metode: Skrining fitokimia infusa daun dandang ...
Ling Ling
doaj   +1 more source

Antagonistic effect of native lactic acid bacteria against foodborne bacterial pathogens [PDF]

open access: yesBihdāsht-i Mavādd-i Ghaz̠āyī, 2018
Identification of lactic acid bacteria, bacteriocin producing has been noticeable by most researchers. The surveys showed that bacteriocins of lactic acid bacteria has antibacterial effect against bacteria of poisoning agent, so these bacteriocins could ...
A. Tarinejad   +2 more
doaj  

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