Results 11 to 20 of about 39,545 (207)

PGLYRP4 Enhances Shigella flexneri Virulence by Promoting virF Transcription via the CpxA/R Two-Component System. [PDF]

Microbiologyopen
Shigella can use the host's innate immune system to optimize the expression of its virulence factors. The PGLYRP4 protein, a member of the host's innate immune system, increases VirF expression in Shigella by stimulating the CpxA/R TCS, thereby enhancing the expression of the virulence system.
Trirocco R, Prosseda G.
europepmc   +2 more sources

Formate Promotes Shigella Intercellular Spread and Virulence Gene Expression

mBio, 2018
The intracellular human pathogen Shigella flexneri invades the colon epithelium, replicates to high cell density within the host cell, and then spreads to adjacent epithelial cells. When S.
Benjamin J. Koestler, Carolyn R. Fisher, Shelley M. Payne   +2 more
doaj   +1 more source

Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes.

PLoS Neglected Tropical Diseases, 2021
No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple serotypes of S. flexneri, which change regionally and globally, also cause significant disease. The
Francesco Citiulo, Francesca Necchi, Francesca Mancini, Omar Rossi, Maria Grazia Aruta, Gianmarco Gasperini, Renzo Alfini, Simona Rondini, Francesca Micoli, Rino Rappuoli, Allan Saul, Laura B Martin   +11 more
doaj   +1 more source

Speciation and Antibiotic Susceptibility Pattern of Shigella isolates in a Rural Tertiary Care Hospital, Kolar

Journal of Pure and Applied Microbiology, 2022
Shigellosis is the most important cause of bacillary dysentery. It’s a major public health problem. It is endemic in many developing countries resulting in a significant amount of mortality and morbidity.
Parimala Subramani, Bharathi Ramachandra, Beena Pavangada Madappa, Arvind Natarajan   +3 more
doaj   +1 more source

Cross-Protective Shigella Whole-Cell Vaccine With a Truncated O-Polysaccharide Chain

Frontiers in Microbiology, 2018
Shigella is a highly prevalent bacterium causing acute diarrhea and dysentery in developing countries. Shigella infections are treated with antibiotics but Shigellae are increasingly resistant to these drugs.
Min Jung Kim, Min Jung Kim, Young-hye Moon, Heejoo Kim, Semi Rho, Young Kee Shin, Manki Song, Richard Walker, Cecil Czerkinsky, Cecil Czerkinsky, Dong Wook Kim, Jae-Ouk Kim   +11 more
doaj   +1 more source

The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]

, 2008
Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Marri, P.R., Ochman, H., Passel, M.W.J., van   +2 more
core   +4 more sources

Shigellosis and toxic megacolon secondary to Shigella flexneri serotype 3a: The challenges of laboratory diagnosis

International Journal of Infectious Diseases, 2018
We present a rare case of Shigella flexneri bacteraemia and toxic megacolon, and discuss the challenges of conventional laboratory techniques versus molecular PCR platforms in differentiating between Shigella species and Escherichia coli.
Emma McGuire, Simon Tiberi, Holly Ciesielczuk, Mark Melzer   +3 more
doaj   +1 more source

Identification of MHC Class II Immunopeptidomes from Shigella flexneri 2a-infected Macrophages as Potential Vaccine Candidates

Indonesian Biomedical Journal, 2022
BACKGROUND: Shigella is a Gram-negative rod-shaped intracellular bacterial pathogen that causes bacterial dysentery or shigellosis among children under five years old.
Nor Raihan Mohammad Shabani, Che Muhammad Khairul Hisyam Ismail, Chiuan Herng Leow, Munirah Mokhtar, Kirnpal Kaur Banga Singh, Chiuan Yee Leow   +5 more
doaj   +1 more source

Characterization of an emergent clone of enteroinvasive Escherichia coli circulating in Europe [PDF]

, 2016
Enteroinvasive Escherichia coli (EIEC) cause intestinal illness indistinguishable from that caused by Shigella, mainly in developing countries. Recently an upsurge of cases of EIEC infections has been observed in Europe, with two large outbreaks ...
Caprioli, A., Dallman, T., Herrera León, S., Jenkins, C., Maugliani, A., Michelacci, V, Morabito, S., PROSSEDA, Gianni, Sanchez, S., Tozzoli, R.   +9 more
core   +1 more source

Aktivitas Antibakteri Kulit Buah Karika Dieng terhadap Shigella flexneri dan Escherichia coli

Jurnal Teknologi Laboratorium, 2018
Karika merupakan tanaman endemik Dataran Tinggi Dieng. Daun Karika telah diteliti memiliki aktivitas antibakteri terhadap bakteri penyebab diare, sedangkan kulit buah dibuang atau dijadikan campuran pakan ternak. Penelitian ini bertujuan untuk mengetahui
Dhiah Novalina, Sugiyarto Sugiyarto, Ari Susilowati   +2 more
doaj   +1 more source