Results 61 to 70 of about 39,545 (207)

Mucosal‐Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 11, November 2025.
Mucosa‐associated invariant T (MAIT) cells are an evolutionarily conserved class of innate‐like T lymphocytes that rely on MR1 molecules to recognize microbial metabolites and play a central role in immune surveillance and inflammatory regulation.
Cheng Zhu   +10 more
wiley   +1 more source

The genomic epidemiology of shigellosis in South Africa

open access: yesNature Communications, 2023
Shigellosis, a leading cause of diarrhoeal mortality and morbidity globally, predominantly affects children under five years of age living in low- and middle-income countries.
George E. Stenhouse   +7 more
doaj   +1 more source

Administration of the NOD2 Agonist MDP Reduces Cryptosporidium parvum Infection in Neonatal Mice Through IL‐22 Involvement

open access: yesEuropean Journal of Immunology, Volume 55, Issue 10, October 2025.
Neonatal mice infected with C. parvum and treated with MDP, a NOD2 agonist, exhibited reduced intestinal infection. This protective effect was mediated by a local immune response involving neutrophil recruitment, IL‐22 production, antimicrobial peptide expression, and epithelial regeneration in an IFN‐γ‐dependent manner.
Mégane Fernandez   +5 more
wiley   +1 more source

Uji Aktivitas Antibakteri Fraksi Etil Asetat Ekstrak Metanol Kulit Buah Manggis (Garcinia Mangostana L.)terhadap Shigella Flexneri [PDF]

open access: yes, 2015
Background: Shigella flexneri is the most common bacteria causeddiarrhea with number of cases increased each year. Mangosteen peel hasbeen used for years by most of Indonesian as a traditional medicine for thetreatment of diarrhea, dysentery, and ...
Saputro, G. M. (Galih)
core   +1 more source

Antibiotic therapy in acute diarrhea associated with Shigella: what is the best option? [PDF]

open access: yes, 2012
Universidade Federal de São Paulo (UNIFESP)Centro Universitário Fundação e Instituto de Educação de Osasco Departamento de Ciências da Saúde Instituto de Pesquisa UnolabUNIFESP Departamento de PediatriaUNIFESP, Depto.
Carrari, Marina H. C.   +2 more
core   +2 more sources

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA)

open access: yesExploration, Volume 5, Issue 5, October 2025.
Multidrug‐resistant Klebsiella pneumoniae poses a significant threat as a nosocomial pathogen, with no current licensed vaccines available. This study used a mutant E. coli strain expressing exogenous polysaccharides (from K. pneumoniae) to establish glycoengineered generalized modules for membrane antigens (geGMMA) vaccine platform, which demonstrated
Jingqin Ye   +13 more
wiley   +1 more source

Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]

open access: yes, 2009
Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
Darling, Aaron E.   +2 more
core  

LPS unmasking of Shigella flexneri reveals preferential localisation of tagged outer membrane protease IcsP to septa and new poles [PDF]

open access: yes, 2013
The Shigella flexneri outer membrane (OM) protease IcsP (SopA) is a member of the enterobacterial Omptin family of proteases which cleaves the polarly localised OM protein IcsA that is essential for Shigella virulence.
A Kaufmann   +50 more
core   +3 more sources

Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent Klebsiella pneumoniae

open access: yesiMeta, Volume 4, Issue 5, October 2025.
The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu   +15 more
wiley   +1 more source

Virulence-Related Gene Distribution Among Shigella Isolates in Anhui, China: The Association with Antimicrobial Resistance

open access: yesInfection and Drug Resistance, 2020
Yanyan Liu,1– 3,* Weihua Shen,4,* Yating Sun,1,* Na Lv,1 Kaili Sun,5 Lifen Hu,1 Ying Ye,1– 3 Yufeng Gao,1– 3 Jiabin Li1– 3,5 1Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei ...
Liu Y   +8 more
doaj  

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