Shigella sonnei: virulence and antibiotic resistance [PDF]
Shigella sonnei is the emerging pathogen globally, as it is the second common infectious species of shigellosis (bloody diarrhoea) in low- and middle-income countries (LMICs) and the leading one in developed world. The multifactorial processes and novel mechanisms have been identified in S. sonnei, that are collectively playing apart a substantial role
Ahtesham Ahmad Shad, Wajahat Ahmed Shad
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Shigella Draft Genome Sequences: Resources for Food Safety and Public Health. [PDF]
Shigella is a major foodborne pathogen that infects humans and nonhuman primates and is the major cause of dysentery and reactive arthritis worldwide. This is the initial public release of 16 Shigella genome sequences from four species sequenced as part ...
Chen, Poyin +5 more
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Clinical implications of reduced susceptibility to fluoroquinolones in paediatric Shigella sonnei and Shigella flexneri infections. [PDF]
OBJECTIVES: We aimed to quantify the impact of fluoroquinolone resistance on the clinical outcome of paediatric shigellosis patients treated with fluoroquinolones in southern Vietnam.
Baker, Stephen +17 more
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Impact of insertion sequences on convergent evolution of Shigella species.
Shigella species are specialised lineages of Escherichia coli that have converged to become human-adapted and cause dysentery by invading human gut epithelial cells.
Jane Hawkey +4 more
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Evaluation of a Live Attenuated S. sonnei Vaccine Strain in the Human Enteroid Model
Shigella is a leading cause of bacillary dysentery worldwide, responsible for high death rates especially among children under five in low–middle income countries.
Giulia Pilla +6 more
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Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]
The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
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Establishment of a Controlled Human Infection Model with a Lyophilized Strain of
Controlled human infection models (CHIMs) are useful for vaccine development. To improve on existing models, we developed a CHIM using a lyophilized preparation of Shigella sonnei strain 53G produced using current good manufacturing practice (cGMP ...
Robert W. Frenck +14 more
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A Cryptic Plasmid from Shigella sonnei [PDF]
pNZ500 is a 1.5 kb cryptic plasmid from a Shigella sonnei isolate. It was introduced into Escherichia coli by cotransformation, where it is maintained at about 30 copies per chromosome equivalent. Hybridization studies show that pNZ500 exhibits a high level of sequence similarity to other 1.5 kb plasmids found in different S. sonnei isolates but shares
J E, Croft, P L, Bergquist, D, Lane
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Symptomatic Shigella sonnei urinary tract infection [PDF]
The clinical course for a patient with symptomatic urinary tract infection due to Shigella sonnei is described. The role of Shigella spp. as urinary pathogens is reviewed.
C J, Papasian +2 more
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Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000–2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin,
Adi Behar +6 more
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