Results 111 to 120 of about 6,960 (169)
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Carcinogenicity of bracken and shikimic acid
Nature, 1974SINCE our initial reports of the carcinogenic potential of bracken for rats and mice1,2 part of our work has been directed towards the isolation of the causative factor(s). The assays used have included acute toxicity testing in mice (orally and intraperitoneally (i.p.)) and mutagen trials with Drosophila and mice, as well as long term cancer induction
I A, Evans, M A, Osman
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A thiobarbituric acid assay for shikimic acid
Analytical Biochemistry, 1963Abstract A sensitive and easily reproducible colorimetric assay has been developed for shikimic acid based on periodate oxidation in concentrated phosphoric acid. The periodate oxidation product reacts with thiobarbituric acid to produce a stable chromogen which, when extracted into cyclohexanone, has an absorption maximum at 535 mμ and an apparent ...
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Enantiospecific synthesis of (-)-5-epi-shikimic acid and a new route to (-)-shikimic acid
Tetrahedron Letters, 1994Abstract (-)-Shikimic acid ( 1 ) and (-)-5- epi -shikimic acid ( 2 ) have each been prepared enantiospecifically and with high diastereoselectivity from D-ribose.
Shende Jiang +3 more
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Shikimic Acid as a Precursor in Lignin Biosynthesis
Nature, 1955THE role of shikimic acid and related compounds in the biosynthesis of the aromatic ring by mutants of E. coli has recently been the subject of extensive study by Davis and his associates1. Their work has indicated that shikimic acid is an important precursor of the aromatic structure in this organism.
S A, BROWN, A C, NEISH
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Nature, 1955
IN a paper describing, inter alia, the isolation of quinic acid from grass1, it was suggested that one of the acids (termed ‘acid B’) present in the grass extracts might be shikimic acid or a closely allied acid. Acid B appeared to be identical with ‘acid G’ found by Davies and Hughes2 in grass and stated by them to be a monobasic acid of relatively ...
A. RICHARDSON, A. C. HULME
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IN a paper describing, inter alia, the isolation of quinic acid from grass1, it was suggested that one of the acids (termed ‘acid B’) present in the grass extracts might be shikimic acid or a closely allied acid. Acid B appeared to be identical with ‘acid G’ found by Davies and Hughes2 in grass and stated by them to be a monobasic acid of relatively ...
A. RICHARDSON, A. C. HULME
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Production and Synthetic Modifications of Shikimic Acid
Chemical Reviews, 2018Shikimic acid is a natural product of industrial importance utilized as a precursor of the antiviral Tamiflu. It is nowadays produced in multihundred ton amounts from the extraction of star anise ( Illicium verum) or by fermentation processes. Apart from the production of Tamiflu, shikimic acid has gathered particular notoriety as its useful carbon ...
Nuno R. Candeias +2 more
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2014
Of the identified biosynthetic paths, shikimic acid pathway plays a very important role in providing precursors of a large number of aromatic compounds of diverse skeletal patterns and substitutions. Chorismic acid, an important branching point product in the shikimic acid pathway also serves as an important precursor. Natural products with C 6 –C 1 or
Sunil Kumar Talapatra, Bani Talapatra
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Of the identified biosynthetic paths, shikimic acid pathway plays a very important role in providing precursors of a large number of aromatic compounds of diverse skeletal patterns and substitutions. Chorismic acid, an important branching point product in the shikimic acid pathway also serves as an important precursor. Natural products with C 6 –C 1 or
Sunil Kumar Talapatra, Bani Talapatra
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Phosphoenolpyruvate Availability and the Biosynthesis of Shikimic Acid
Biotechnology Progress, 2003The impact of increased availability of phosphoenolpyruvate during shikimic acid biosynthesis has been examined in Escherichia coli K-12 constructs carrying plasmid-localized aroF(FBR) and tktA inserts encoding, respectively, feedback-insensitive 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase and transketolase.
Sunil S, Chandran +5 more
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Evaluation of shikimic acid as a precursor of pyocyanine
Canadian Journal of Microbiology, 1969The availability of a new resuspension medium and the isolation of a strain of Pseudomonas aeruginosa unable to use quinic acid for growth have facilitated the evaluation of shikimic and quinic acids as precursors of pyocyanine. Shikimic acid or its derivatives were shown to account for virtually 100% of the carbon atoms of the phenazine nucleus of ...
W M, Ingledew, J J, Campbell
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Interaction of shikimic acid with shikimate kinase.
Biochemical and biophysical research communications, 2005The crystal structure of shikimate kinase from Mycobacterium tuberculosis (MtSK) complexed with MgADP and shikimic acid (shikimate) has been determined at 2.3A resolution, clearly revealing the amino acid residues involved in shikimate binding. In MtSK, the Glu61 strictly conserved in SK forms a hydrogen bond and salt-bridge with Arg58 and assists in ...
José Henrique, Pereira +7 more
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