Results 131 to 140 of about 8,230 (185)
Some of the next articles are maybe not open access.
Biotechnology Advances, 2012
Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir (Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation and extraction from certain plants. An alternative production route is via biotransformation of the more readily available quinic acid.
Saptarshi, Ghosh +2 more
openaire +2 more sources
Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir (Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation and extraction from certain plants. An alternative production route is via biotransformation of the more readily available quinic acid.
Saptarshi, Ghosh +2 more
openaire +2 more sources
Biotechnology and Bioengineering, 2005 Shikimic acid is one of several industrially interesting chiral starting materials formed in the aromatic amino acid pathway of plants and microorganisms. In this study, the physiology of a shikimic acid producing strain of Escherichia coli (derived from
KRISTIAN Fog Nielsen, Gunnar Liden
exaly +2 more sources
Separation and Purification Technology, 2014 Shikimic acid is a main raw intermediate for manufacturing oseltamivir phosphate (Tamiflu), which is the only antiviral treatment for Influenzavirus A (H5N1 and H2N1), recently.
Ming Cai, Hanhua Liang, Peilong Sun
exaly +2 more sources
Carcinogenicity of bracken and shikimic acid
Nature, 1974SINCE our initial reports of the carcinogenic potential of bracken for rats and mice1,2 part of our work has been directed towards the isolation of the causative factor(s). The assays used have included acute toxicity testing in mice (orally and intraperitoneally (i.p.)) and mutagen trials with Drosophila and mice, as well as long term cancer induction
I A, Evans, M A, Osman
openaire +2 more sources
Enantiospecific synthesis of (-)-5-epi-shikimic acid and a new route to (-)-shikimic acid
Tetrahedron Letters, 1994Abstract (-)-Shikimic acid ( 1 ) and (-)-5- epi -shikimic acid ( 2 ) have each been prepared enantiospecifically and with high diastereoselectivity from D-ribose.
Shende Jiang +3 more
openaire +1 more source
Shikimic Acid as a Precursor in Lignin Biosynthesis
Nature, 1955THE role of shikimic acid and related compounds in the biosynthesis of the aromatic ring by mutants of E. coli has recently been the subject of extensive study by Davis and his associates1. Their work has indicated that shikimic acid is an important precursor of the aromatic structure in this organism.
S A, BROWN, A C, NEISH
openaire +2 more sources
A thiobarbituric acid assay for shikimic acid
Analytical Biochemistry, 1963Abstract A sensitive and easily reproducible colorimetric assay has been developed for shikimic acid based on periodate oxidation in concentrated phosphoric acid. The periodate oxidation product reacts with thiobarbituric acid to produce a stable chromogen which, when extracted into cyclohexanone, has an absorption maximum at 535 mμ and an apparent ...
openaire +2 more sources
Nature, 1955
IN a paper describing, inter alia, the isolation of quinic acid from grass1, it was suggested that one of the acids (termed ‘acid B’) present in the grass extracts might be shikimic acid or a closely allied acid. Acid B appeared to be identical with ‘acid G’ found by Davies and Hughes2 in grass and stated by them to be a monobasic acid of relatively ...
A. RICHARDSON, A. C. HULME
openaire +1 more source
IN a paper describing, inter alia, the isolation of quinic acid from grass1, it was suggested that one of the acids (termed ‘acid B’) present in the grass extracts might be shikimic acid or a closely allied acid. Acid B appeared to be identical with ‘acid G’ found by Davies and Hughes2 in grass and stated by them to be a monobasic acid of relatively ...
A. RICHARDSON, A. C. HULME
openaire +1 more source
Production and Synthetic Modifications of Shikimic Acid
Chemical Reviews, 2018Shikimic acid is a natural product of industrial importance utilized as a precursor of the antiviral Tamiflu. It is nowadays produced in multihundred ton amounts from the extraction of star anise ( Illicium verum) or by fermentation processes. Apart from the production of Tamiflu, shikimic acid has gathered particular notoriety as its useful carbon ...
Nuno R. Candeias +2 more
openaire +2 more sources
2014
Of the identified biosynthetic paths, shikimic acid pathway plays a very important role in providing precursors of a large number of aromatic compounds of diverse skeletal patterns and substitutions. Chorismic acid, an important branching point product in the shikimic acid pathway also serves as an important precursor. Natural products with C 6 –C 1 or
Sunil Kumar Talapatra, Bani Talapatra
openaire +1 more source
Of the identified biosynthetic paths, shikimic acid pathway plays a very important role in providing precursors of a large number of aromatic compounds of diverse skeletal patterns and substitutions. Chorismic acid, an important branching point product in the shikimic acid pathway also serves as an important precursor. Natural products with C 6 –C 1 or
Sunil Kumar Talapatra, Bani Talapatra
openaire +1 more source