Results 111 to 120 of about 997,380 (276)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Combination of nucleated red blood cells and inflammatory biomarkers (PCT and CRP) for predicting sepsis and septic shock in children

Frontiers in Cellular and Infection Microbiology
IntroductionSepsis remains a leading cause of mortality and morbidity worldwide. This study aimed to investigate the clinical characteristics of children with sepsis and septic shock, with emphasis to evaluate the predictive value of C-reactive protein ...
Kaibin Pu, Kaibin Pu, Kaibin Pu, Chunyi Wang, Jie Cheng, Jie Cheng, Jie Cheng, Dapeng Chen, Liping Tan, Liping Tan, Liping Tan, Jihong Tan, Jihong Tan, Jihong Tan, Hongdong Li, Hongdong Li, Hongdong Li   +16 more
doaj   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Intensive Care Medicine, 2017
A. Rhodes, Laura Evans, W. Alhazzani, Mitchell M. Levy, M. Antonelli, R. Ferrer, Anand Kumar, J. Sevransky, C. L. Sprung, M. Nunnally, B. Rochwerg, G. D. Rubenfeld, D. Angus, D. Annane, Richard J. Beale, Geoffrey J. Bellinghan, Gordon R. Bernard, J. Chiche, C. Coopersmith, Daniel De Backer, Craig French, Seitaro Fujishima, H. Gerlach, Jorge L. Hidalgo, S. Hollenberg, Alan E. Jones, Dilip R. Karnad, R. Kleinpell, Younsuck Koh, Thiago Lisboa, Flavia R Machado, John J. Marini, John C. Marshall, J. Mazuski, Lauralyn A. McIntyre, A. McLean, S. Mehta, Rui P. Moreno, J. Myburgh, P. Navalesi, O. Nishida, Tiffany M. Osborn, A. Perner, Colleen M. Plunkett, Marco Ranieri, Christa A. Schorr, Maureen A. Seckel, Christopher W. Seymour, L. Shieh, Khalid A. Shukri, Steven Q Simpson, M. Singer, B. T. Thompson, S. Townsend, T. van der Poll, Jean-Louis Vincent, W. J. Wiersinga, Janice L. Zimmerman, R. Dellinger   +58 more
semanticscholar   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Predicting patients with septic shock and sepsis through analyzing whole-blood expression of NK cell-related hub genes using an advanced machine learning framework

Frontiers in Immunology
BackgroundSepsis is a life-threatening condition that causes millions of deaths globally each year. The need for biomarkers to predict the progression of sepsis to septic shock remains critical, with rapid, reliable methods still lacking. Transcriptomics
Chao Du, Chao Du, Chao Du, Stephanie C. Tan, Stephanie C. Tan, Heng-Fu Bu, Heng-Fu Bu, Saravanan Subramanian, Saravanan Subramanian, Hua Geng, Hua Geng, Xiao Wang, Xiao Wang, Hehuang Xie, Xiaowei Wu, Tingfa Zhou, Ruijin Liu, Zhen Xu, Bing Liu, Xiao-Di Tan, Xiao-Di Tan, Xiao-Di Tan   +21 more
doaj   +1 more source