Results 171 to 180 of about 148,592 (309)

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Medical analysis and diagnosis by neural networks

, 2010
In its first part, this contribution reviews shortly the application of neural network methods to medical problems and characterizes its advantages and problems in the context of the medical background.
Brause, Rüdiger W.
core  

Red Blood Cell Transfusion Beyond Restrictive Thresholds in Patients With Septic Shock and an Elevated Lactate Level: A Multicenter Observational Study. [PDF]

J Korean Med Sci
Yoo KH, Suh GJ, Kwon WY, Choi SH, Chung SP, Kim WY, Kim K, Park YS, Shin TG, Ko BS, Lim TH, Cho Y, Korean Shock Society (KoSS) Investigators.   +12 more
europepmc   +1 more source

The Glutamate-Glutamine Axis in Pediatric Septic Shock: Immunometabolic Mechanisms, Biomarker Potential, and Clinical Implications. [PDF]

Int J Mol Sci
Cui Y, Wang J, Bao Y.
europepmc   +1 more source

Vasopressors in septic shock: a systematic review and network meta-analysis

, 2015
Feihu Zhou,1,* Zhi Mao,1,* Xiantao Zeng,2,* Hongjun Kang,1 Hui Liu,1 Liang Pan,1 Peter C Hou31Department of Critical Care Medicine, Chinese People’s Liberation Army General Hospital, Beijing, 2Center for Evidence-Based and Translational Medicine ...
Liu H, Zhou FH, Kang HJ, Hou PC, Pan L, Mao Z, Zeng XT   +6 more
core  

Risk factors for 28-day mortality and pathogen characteristics of septic shock in children: a 10-year retrospective cohort study. [PDF]

Front Cell Infect Microbiol
Wang Y, Chen G, Zhai N, Li B, Feng X, Hu R, Xiao S.   +6 more
europepmc   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

The Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson, Pierre Frémondière, Kaspar Staub, Philipp Mitteroecker, Barbara Fischer, Martin Haeusler, Nicole M. Webb   +6 more
wiley   +1 more source

Are Inflammatory Biomarkers at ICU Discharge Still Predictive of Post-ICU Mortality in Sepsis and Septic Shock? A Retrospective, Single-Center Cohort Study. [PDF]

J Clin Med
Ay M, Sari R.
europepmc   +1 more source

Historical birth records from 1896 to 1944 from the Basel maternity hospital, Switzerland, reveal significant obstetric selection pressures

The Anatomical Record, EarlyView.
Abstract Maternal and neonatal morbidity and mortality have declined dramatically during the last century. Historical data are therefore important sources to study the evolutionary selection pressures related to childbirth and how they have fluctuated over time.
Mirella Woodert, Guillermo Bravo Morante, Viktoria A. Krenn, Cédric Cordey, Nicole Torres‐Tamayo, Kaspar Staub, Nicole M. Webb, Martin Haeusler   +7 more
wiley   +1 more source

Postoperative Septic Shock After Esophagectomy for Esophageal Cancer: Risk Factors and Impact on Short- and Long-Term Survival. [PDF]

J Pers Med
Piñeiro P, Sánchez F, Calvo A, Tudela M, Ramos S, García S, Benito P, Solchaga I, Vela R, Menéndez C, Cabezuelo E, Garutti I.   +11 more
europepmc   +1 more source