Results 31 to 40 of about 610,317 (302)

A model of porcine polymicrobial septic shock

Intensive Care Medicine Experimental, 2023
Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades.
Finnja Marie Zurek-Leffers, Florian Lehmann, Laura Brabenec, Sebastian Kintrup, Katharina E. M. Hellenthal, Kira Mersjann, Felicia Kneifel, Michael Hessler, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Christian Ertmer, Patrick Kellner, Nana-Maria Wagner   +12 more
doaj   +1 more source

Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study

Frontiers in Medicine, 2022
IntroductionSeptic shock, largely caused by intestinal perforation, is the most common critical illness in intensive care unit (ICU). As an important quality control strategy in ICU, deep vein thrombosis (DVT) prevention is routinely used in the ...
Lu Wang, Xudong Ma, Huaiwu He, Longxiang Su, Yanhong Guo, Guangliang Shan, Ye Wang, Xiang Zhou, Dawei Liu, Yun Long   +9 more
doaj   +1 more source

Protein C preserves microcirculation in a model of neonatal septic shock [PDF]

, 2009
Objectives: Sepsis remains a disease with a high mortality in neonates. Microcirculatory impairment plays a pivotal role in the development of multiorgan failure in septic newborns.
Nold, Marcel Friedrich, Nold-Petry, Claudia A., Furlan, Antonio, Veldman, Alex, Fischer, Doris   +4 more
core   +1 more source

Rate of Admission and Risk Factors of Sepsis and Septic Shock Patients in Emergency Intensive Care Unit [PDF]

Zagazig University Medical Journal
Background: Every year, millions of people are affected with sepsis and septic shock, which pose significant challenges to healthcare providers. Septic shock is the most severe form of sepsis.
Hatem Raafat Mostafa El-Malah, Adel Botros, Khaled Abdelhameed   +2 more
doaj   +1 more source

Arterial catheterization and in-hospital mortality in sepsis: a propensity score-matched study

BMC Anesthesiology, 2022
Background Despite the extensive use of arterial catheterization (AC), clinical effectiveness of AC to alter the outcomes among patients with sepsis and septic shock has not been evaluated.
Qitian Ou, Gengxin Cai, Yuan Zhou, Wanjie Zha, Linqiang Huang, Hongke Zeng, Wenqiang Jiang, Shenglong Chen, Miaoyun Wen   +8 more
doaj   +1 more source

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. [PDF]

, 2010
In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on ...
Aladzsity, István, Prohászka Zoltán, Madách Krisztina, Füst György, Pénzes, István, Gál János, Pénzes István, Madách, Krisztina, Prohászka, Zoltán, Szilágyi Ágnes, Aladzsity István, Szilágyi, Agnes, Fust, George, Gál, János   +13 more
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The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source

Major sepsis study confirms back to basics approach [PDF]

, 2014
In 2001 Rivers et al. published a landmark study in the New England Journal of Medicine showing that in a single centre, involving patients presenting to an emergency department with severe sepsis and septic shock, an early goal-directed therapy (EGDT ...
Nathwani, D.
core   +1 more source

Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis

Медицинская иммунология, 2020
Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj   +1 more source

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. [PDF]

, 2014
BACKGROUND: Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated ...
McAuley, Daniel F, Orme, RML, Singer, M, L'E Orme, Robert M, Alexina J Mason, McAuley DF, Mason, Alexina J., Orme, Robert M L'E, Ashby D, Orme, Robert M., Mason, Alexina J, Liu, KD, Perkins, Gavin D., McAuley, Daniel F.; id_orcid, Gordon, Anthony C., Robert M Orme, Daniel F McAuley, Mason, AJ, Gordon, Anthony C, Gordon AC, Liu, Kathleen D., Orme RM, Gordon, AC, Mervyn Singer, Perkins, GD, Kathleen D Liu, Mason AJ, McAuley, Daniel F., Liu KD, Andrea Morelli, Ashby, D, Liu, Kathleen, Liu, Kathleen D, Gavin D Perkins, Morelli, A, Singer, Mervyn, Singer M, Perkins, Gavin D, Ashby, Deborah, Anthony C Gordon, Deborah Ashby, Orme, Robert MLE, Morelli, Andrea, Perkins GD, McAuley, DF   +44 more
core   +1 more source