Results 11 to 20 of about 1,604,851 (310)

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Critical Care, 2020
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer, H. Gerlach, T. Vogelmann, F. Preissing, J. Stiefel, D. Adam   +5 more
semanticscholar   +1 more source

Extended resuscitative endovascular balloon occlusion of the aorta (REBOA)-induced type 2 myocardial ischemia: a time-dependent penalty

Trauma Surgery & Acute Care Open, 2019
Background Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) increases cardiac-afterload and is used for patients in hemorrhagic shock. The cardiac tolerance of prolonged afterload augmentation in this context is unknown.
Thomas M Scalea, Jonathan J Morrison, Philip J Wasicek, William A Teeter, Melanie R Hoehn, Shiming Yang, Hector Banchs, Samuel M Galvagno, Peter Hu, William B Gamble   +9 more
doaj   +1 more source

Lower Extremity Staged Revascularization (LESR) as a new innovative concept for lower extremity salvage in acute popliteal artery injuries: a hypothesis

Patient Safety in Surgery, 2022
Popliteal artery injury following knee dislocation is associated with significant morbidity and high amputation rates. The complex and multi-disciplinary input required to manage this injury effectively can take time to arrange, prolonging the time to ...
Joseph Edwards, Rebecca N. Treffalls, Hossam Abdou, David P. Stonko, Patrick F. Walker, Jonathan J. Morrison   +5 more
doaj   +1 more source

Shock the heat shock network [PDF]

Journal of Clinical Investigation, 2009
The targeting of tumors is made possible through establishing protein signatures specific for each cancer type. The recent recognition of the higher expression levels of HSP90 and its accumulation in tumor cell mitochondria has made the HSP90 network a feasible target for neutralization.
Cigdem, Atay, Serkan, Ugurlu, Nesrin, Ozören   +2 more
openaire   +2 more sources

c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock

Molecular Medicine, 2022
Background Our previous data demonstrated that miR-19b expression was increased in human lung microvascular endothelial cells in-vitro-, in-vivo and in patients with hemorrhagic shock, leading to a decrease in syndecan-1 mRNA and protein and resulting in
Feng Wu, Jian-Ying Wang, Brooke Dorman, Ahmad Zeineddin, Rosemary Ann Kozar   +4 more
doaj   +1 more source

Expression of hemoglobin α and β subunits in different types of rat vasculatures

Di-san junyi daxue xuebao, 2022
Objective To clarify whether hemoglobin (Hb) α and β subunits are expressed in rat blood vessels, and whether there are differences in expression levels between different types of vasculatures.
ZANG Jiatao, LI Qinghui, WU Yue, ZHANG Zisen, LIU Liangming   +4 more
doaj   +1 more source

Nonlinear isolation performance of 6 × 19 wire rope of different lengths under compression

Advances in Mechanical Engineering, 2021
Stainless steel wire rope isolator is widely used in engineering. To optimize design of the isolator, loading, and unloading characteristics of the 6 × 19 6 mm wire rope under compression are investigated. Ropes of different lengths are tested to get the
Genlin Mo, Jing Liu, Yongxi Jin, Wenmin Yan   +3 more
doaj   +1 more source

Quantitative analysis of intermuscular septa in the leg: implications for trauma surgery

Trauma Surgery & Acute Care Open, 2021
Background Compartment syndrome is the excess swelling within an inelastic compartment leading to excessive compartment pressure. Lower limb trauma has a high risk of compartment syndrome, which is typically mitigated using a two-incision fasciotomy. Our
Samuel Tisherman, Lorreen Agandi, Kristina Fuller, Kristin Sonderman, Adam C Puche   +4 more
doaj   +1 more source

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

Intensive Care Medicine, 2013
ObjectiveTo provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008.DesignA consensus committee of 68 international experts representing 30 international organizations was ...
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno, The Surviving Sepsis Campaign Guidelines Committee inc Subgroup   +23 more
semanticscholar   +1 more source

Cardiogenic Shock After Acute Myocardial Infarction: A Review.

Journal of the American Medical Association (JAMA), 2021
Importance Cardiogenic shock affects between 40 000 and 50 000 people in the US per year and is the leading cause of in-hospital mortality following acute myocardial infarction.
Marc D. Samsky, D. Morrow, A. Proudfoot, J. Hochman, H. Thiele, S. Rao   +5 more
semanticscholar   +1 more source