Results 11 to 20 of about 3,407,262 (376)

Shock the heat shock network [PDF]

Journal of Clinical Investigation, 2009
The targeting of tumors is made possible through establishing protein signatures specific for each cancer type. The recent recognition of the higher expression levels of HSP90 and its accumulation in tumor cell mitochondria has made the HSP90 network a feasible target for neutralization.
Serkan Uǧurlu, Nesrin Özören, Çiǧdem Atay   +2 more
openaire   +2 more sources

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the validity of this definition.
M. Shankar-Hari, Gary S. Phillips, M. Levy, C. Seymour, Vincent X. Liu, C. Deutschman, D. Angus, G. Rubenfeld, M. Singer   +8 more
semanticscholar   +1 more source

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Critical Care, 2020
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer, H. Gerlach, T. Vogelmann, F. Preissing, J. Stiefel, D. Adam   +5 more
semanticscholar   +1 more source

c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock

Molecular Medicine, 2022
Background Our previous data demonstrated that miR-19b expression was increased in human lung microvascular endothelial cells in-vitro-, in-vivo and in patients with hemorrhagic shock, leading to a decrease in syndecan-1 mRNA and protein and resulting in
Feng Wu, Jian-Ying Wang, Brooke Dorman, Ahmad Zeineddin, Rosemary Ann Kozar   +4 more
doaj   +1 more source

Numerical investigation on unsteady force suppression of pump-jet rotor by oscillating stator trailing edge flaps

Zhongguo Jianchuan Yanjiu, 2023
ObjectivesThe unsteady force of the rotor is the main excitation source of pump-jet shafting vibration, and rotor-stator interaction has an important impact on the characteristics of the unsteady force.
Wanghao TANG, Xiuchang HUANG, Zhiqiang RAO, Hongxing HUA   +3 more
doaj   +1 more source

The open string membrane paradigm with external electromagnetic fields [PDF]

, 2011
We study the effective geometry felt by the fluctuations of open strings living on the worldvolume of probe D-branes in the presence of background electromagnetic fields.
Kim, Keun-Young, Shock, Jonathan P., Tarrio, Javier   +2 more
core   +3 more sources

Characterization of cerebral blood flow during open cardiac massage in swine: Effect of volume status

Frontiers in Physiology, 2022
Introduction: Patients in cardiac arrest treated with resuscitative thoracotomy and open cardiac massage (OCM) have high rates of mortality with poor neurological outcomes.
Neerav Patel, Joseph Edwards, Hossam Abdou, David P. Stonko, David P. Stonko, Rebecca N. Treffalls, Noha N. Elansary, Thomas Ptak, Jonathan J. Morrison   +8 more
doaj   +1 more source

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

Intensive Care Medicine, 2013
ObjectiveTo provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008.DesignA consensus committee of 68 international experts representing 30 international organizations was ...
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno, The Surviving Sepsis Campaign Guidelines Committee inc Subgroup   +23 more
semanticscholar   +1 more source

Nonlinear isolation performance of 6 × 19 wire rope of different lengths under compression

Advances in Mechanical Engineering, 2021
Stainless steel wire rope isolator is widely used in engineering. To optimize design of the isolator, loading, and unloading characteristics of the 6 × 19 6 mm wire rope under compression are investigated. Ropes of different lengths are tested to get the
Genlin Mo, Jing Liu, Yongxi Jin, Wenmin Yan   +3 more
doaj   +1 more source

Entanglement entropy of $\alpha$-vacua in de Sitter space [PDF]

, 2014
We consider the entanglement entropy of a free massive scalar field in the one parameter family of $\alpha$-vacua in de Sitter space by using a method developed by Maldacena and Pimentel.
Kanno, Sugumi, Murugan, Jeff, Shock, Jonathan P., Soda, Jiro   +3 more
core   +2 more sources