Results 21 to 30 of about 743,677 (269)

Characterization of cerebral blood flow during open cardiac massage in swine: Effect of volume status

Frontiers in Physiology, 2022
Introduction: Patients in cardiac arrest treated with resuscitative thoracotomy and open cardiac massage (OCM) have high rates of mortality with poor neurological outcomes.
Neerav Patel, Joseph Edwards, Hossam Abdou, David P. Stonko, David P. Stonko, Rebecca N. Treffalls, Noha N. Elansary, Thomas Ptak, Jonathan J. Morrison   +8 more
doaj   +1 more source

Expression of hemoglobin α and β subunits in different types of rat vasculatures

Di-san junyi daxue xuebao, 2022
Objective To clarify whether hemoglobin (Hb) α and β subunits are expressed in rat blood vessels, and whether there are differences in expression levels between different types of vasculatures.
ZANG Jiatao, LI Qinghui, WU Yue, ZHANG Zisen, LIU Liangming   +4 more
doaj   +1 more source

Nonlinear isolation performance of 6 × 19 wire rope of different lengths under compression

Advances in Mechanical Engineering, 2021
Stainless steel wire rope isolator is widely used in engineering. To optimize design of the isolator, loading, and unloading characteristics of the 6 × 19 6 mm wire rope under compression are investigated. Ropes of different lengths are tested to get the
Genlin Mo, Jing Liu, Yongxi Jin, Wenmin Yan   +3 more
doaj   +1 more source

Quantitative analysis of intermuscular septa in the leg: implications for trauma surgery

Trauma Surgery & Acute Care Open, 2021
Background Compartment syndrome is the excess swelling within an inelastic compartment leading to excessive compartment pressure. Lower limb trauma has a high risk of compartment syndrome, which is typically mitigated using a two-incision fasciotomy. Our
Samuel Tisherman, Lorreen Agandi, Kristina Fuller, Kristin Sonderman, Adam C Puche   +4 more
doaj   +1 more source

Uncertainty Shocks are Aggregate Demand Shocks [PDF]

Federal Reserve Bank of San Francisco, Working Paper Series, 2012
Abstract Search frictions in the labor market give rise to a new option-value channel through which uncertainty affects aggregate economic activity, and the effects of which are reinforced by the presence of nominal rigidities. With these features, an increase in uncertainty resembles an aggregate demand shock because it increases unemployment and ...
Sylvain Leduc, Zheng Liu
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source