Results 41 to 50 of about 2,691,050 (352)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

A swine model of reproducible timed induction of peripheral arterial shunt failure: Developing warning signs of imminent shunt failure

JVS - Vascular Science, 2022
Temporary intravascular shunts are used to maintain perfusion in injured vessels, although failure can be unpredictable and lead to significant morbidity.
David P. Stonko, MD, MS, Neerav Patel, MD, Joseph Edwards, MD, Hossam Abdou, MD, Eric Lang, BS, Noha N. Elansary, BS, Rebecca Treffalls, BS, Joseph White, MD, Jonathan J. Morrison, MBChB, PhD   +8 more
doaj   +1 more source

A Coronal Hole's Effects on CME Shock Morphology in the Inner Heliosphere

, 2012
We use STEREO imagery to study the morphology of a shock driven by a fast coronal mass ejection (CME) launched from the Sun on 2011 March 7. The source region of the CME is located just to the east of a coronal hole. The CME ejecta is deflected away from
A. P. Rouillard, B. E. Wood, Bevington, Billings, C.-C. Wu, Chen, D. G. Socker, Gibson, Krall, Press, R. A. Howard, Sheeley, Shu, Thernisien, Wood, Wood, Wood   +16 more
core   +1 more source

On imploding cylindrical and spherical shock waves in a perfect gas [PDF]

, 2006
The problem of a cylindrically or spherically imploding and reflecting shock wave in a flow initially at rest is studied without the use of the strong-shock approximation.
Hornung, H. G., Mouton, C. A., Ponchaut, N. F., Pullin, D. I.   +3 more
core   +1 more source

Multiple shocks [PDF]

Journal of High Energy Physics, 2014
Using gauge/gravity duality, we explore a class of states of two CFTs with a large degree of entanglement, but with very weak local two-sided correlation. These states are constructed by perturbing the thermofield double state with thermal-scale operators that are local at different times.
Shenker, Stephen, Stanford, Douglas
openaire   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Study on force spectrum characteristics of a pump-jet under inflow turbulence

Zhongguo Jianchuan Yanjiu, 2022
Objectives This paper aims to clarify the characteristics of the unsteady force spectrum of a pump-jet operating under inflow turbulence. MethodsThe turbulence grid and Fourier synthesis method are employed to produce inflow turbulence with spatial flow ...
Shuaikang SHI, Xiuchang HUANG, Zhiqiang RAO, Hongxing HUA   +3 more
doaj   +1 more source

Reverse undercompressive shock structures in driven thin film flow

, 2002
We show experimental evidence of a new structure involving an undercompressive and reverse undercompressive shock for draining films driven by a surface tension gradient against gravity.
A. L. Bertozzi, A. L. Bertozzi, A. M. Cazabat, Andrea L. Bertozzi, H. E. Huppert, Jeanman Sur, M. Schneemilch, Robert P. Behringer, S. M. Troian, T. G. Myers, V. Ludviksson   +10 more
core   +1 more source

Universal hydrodynamic flow in holographic planar shock collisions [PDF]

, 2015
We study the collision of planar shock waves in AdS$_5$ as a function of shock profile. In the dual field theory the shock waves describe planar sheets of energy whose collision results in the formation of a plasma which behaves hydrodynamically at late ...
Chesler, Paul M., Kilbertus, Niki, van der Schee, Wilke   +2 more
core   +6 more sources