Results 141 to 150 of about 242,487 (311)
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Propionyl CoA production from odd-chain fatty acids
, 1997 Beta-oxidation of fatty acids with an odd number of carbons inthe chain yields the three-carbon propionyl CoA as the final ...
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PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
Fatty acid reductases (FAR): Insights into the biosynthesis of fatty alcohols in plants and bacteria [PDF]
, 2011 Primary fatty alcohols are present in all phyla, where they serve various unique biological functions, either in structural materials or biochemical compounds.
Doan, Thuy
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Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Immunomodulating activity of short-chain fatty acids
, 2021 Kratkolančane masne kiseline (SCFA) nastaju bakterijskom fermentacijom neprobavljivih komponenata hrane u gastrointestinalnom traktu. Najzastupljenije bakterije koje proizvode kratkolančane masne kiseline su iz odjeljaka Bacteroidetes i Firmicutes ...
Kralj-Vrsalović, Paula
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MicroorganismsThe production of municipal sludge is steadily increasing in line with the production of sewage. A wealth of organic contaminants, including nutrients and energy, are present in municipal sludge.
Yuhao Liu +6 more
doaj +1 more source
Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome
Advanced Science, EarlyView.We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu +19 more
wiley +1 more source
Fish fatty acids and mental health in older people
, 2009 Background It has been suggested that the intake of fish and marine n-3 polyunsaturated fatty acids could protect against age-related cognitive decline and impaired mental well-being. However, results from observational studies are inconclusive and data
Rest, O., van de, van de Rest, O.
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Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source