Results 261 to 270 of about 5,590,230 (287)

Analysis of Short-read Aligners using Genome Sequence Complexity

2020 12th International Conference on Knowledge and Systems Engineering (KSE), 2020
Next generation sequencing technologies have the capability to provide large numbers of short reads inexpensively and accurately. Researchers have proposed many different methods to align short reads to reference genomes. Nevertheless, long repeats, which are known to be abundant in eukaiyotic genomes, have caused considerable difficulty for genome ...
Quang Tran 0002, Nam Sy Vo, Eric Hicks, Tin Chi Nguyen, Vinhthuy Phan   +4 more
openaire   +2 more sources

Detecting Signatures of TE Polymorphisms in Short-Read Sequencing Data

2021
Transposable elements (TEs) are an important cause of evolutionary change and functional diversity, yet they are routinely discarded in the first steps of many analyses. In this chapter we show how, given a reference genome, TEs can be incorporated fairly easily into functional and evolutionary studies.
Stritt, Christoph, Roulin, Anne C
openaire   +2 more sources

An algorithm for mapping short reads to a dynamically changing genomic sequence

2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2010
The constant advances in sequencing technology have redefined the way genome sequencing is performed. They are able to produce tens of millions of short sequences (reads), during a single experiment, and with a much lower cost than previously possible.
Tomás Flouri, Jan Holub 0001, Costas S. Iliopoulos, Solon P. Pissis   +3 more
openaire   +3 more sources

Innovations in Short-Read Sequencing Technologies and Their Applications to Clinical Genomics

Clinical Chemistry
Abstract Background Massively parallel sequencing (MPS) of nucleic acids has been a transformative technology for basic and applied genomic science, increasing efficiencies and decreasing costs to enable studies of unprecedented scope and impact.
Katarzyna Polonis, Joseph H Blommel, Andrew E O Hughes, David Spencer, Joseph A Thompson, Molly C Schroeder   +5 more
openaire   +2 more sources

HLA Typing from Short-Read Sequencing Data with OptiType

2018
The established standards for HLA genotyping rely on targeted DNA sequencing techniques. However, the increasing abundance of short-read sequencing data has prompted a demand for computational tools capable of HLA typing from general purpose sequencing data as well.
openaire   +2 more sources

Innovative technologies crowd the short-read sequencing market

Nature, 2023
openaire   +2 more sources

Optical Genome Mapping and Revisiting Short-Read Genome Sequencing Data Reveal Previously Overlooked Structural Variants Disrupting Retinal Disease−Associated Genes

Genetics in Medicine, 2023
Suzanne E de Bruijn, Marcel R Nelen
exaly  

Oxford Nanopore R10.4 Long-Read Sequencing Enables the Generation of Near-Finished Bacterial Genomes From Pure Cultures and Metagenomes Without Short-Read or Reference Polishing

Nature Methods, 2022
Mantas Sereika, Thomas Yssing Michaelsen, Søren M Karst   +2 more
exaly  

Finding the Right Fit: Evaluation of Short-Read and Long-Read Sequencing Approaches to Maximize the Utility of Clinical Microbiome Data

Microbial Genomics, 2022
Jeanette L Gehrig, Daniel M. Portik, Eric Jackson   +2 more
exaly  

Aligning Short Sequencing Reads With Bowtie

Current Protocols in Bioinformatics, 2010
Benjamin Langmead
exaly