Results 251 to 260 of about 5,590,230 (287)

Complete Reference Genome and Pangenome Expand Biologically Relevant Information for Genome-Wide DNA Methylation Analysis Using Short-Read Sequencing and Array Data

Dong Z(, Whitehead J, Fu M, MacIsaac JL, Rehkopf DH, Rosero-Bixby L, Kobor MS, Korthauer K.   +7 more
europepmc   +1 more source

Comparison of Structural and Short Variants Detected by Linked-Read and Whole-Exome Sequencing in Multiple Myeloma [PDF]

Cancers, 2021
Linked-read sequencing was developed to aid the detection of large structural variants (SVs) from short-read sequencing efforts. We performed a systematic evaluation to determine if linked-read exome sequencing provides more comprehensive and clinically ...
Ashwini Kumar, Caroline A Heckman, Matti Kankainen   +2 more
exaly   +2 more sources

A Review on Sequence Alignment Algorithms for Short Reads Based on Next-Generation Sequencing [PDF]

IEEE Access, 2020
With recent advances in next-generation sequencing (NGS) technology, large volumes of data have been produced in the form of short reads. Sequence assembly involves using initial short reads to produce progressively longer contigs, and then using scaffolds to produce the final sequence.
Jeongkyu Kim, Gangman Yi, Mingeun Ji
exaly   +3 more sources

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Short-Read Sequencing Technologies for Transcriptional Analyses

Annual Review of Plant Biology, 2009
The technological advances in DNA sequencing over the past five years have changed our approaches to gene expression analysis, fundamentally altering the basic methods used and in most cases driving a shift from hybridization-based approaches to sequencing-based approaches.
Stacey A, Simon, Jixian, Zhai, Raja Sekhar, Nandety, Kevin P, McCormick, Jia, Zeng, Diego, Mejia, Blake C, Meyers   +6 more
openaire   +2 more sources

The Untapped Potential of Short-Read Sequencing in Biodiversity Research

Trends in Genetics
The power of short-read DNA sequencing in biodiversity research and evolutionary genomics is rapidly growing due to advances in technology and bioinformatics. Short-read sequencing offers powerful solutions for taxonomic identification, biomass estimation, and phylogenetic reconstruction.
Christoph Bleidorn, Lars Podsiadlowski, Alfried P. Vogler   +2 more
exaly   +4 more sources

Mapping short reads to a genomic sequence with circular structure

Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine, 2010
Constant advances in DNA sequencing technologies are turning whole-genome sequencing into a routine procedure, resulting in massive amounts of data that need to be processed. Tens of gigabytes of data, in the form of short sequences (reads), need to be mapped back onto reference sequences, a few gigabases long.
Flouri, Tomas, Iliopoulos, Costas S., Pissis, Solon P., Tischler, German   +3 more
openaire   +3 more sources

Short read sequencing in studies of natural variation and adaptation

Current Opinion in Plant Biology, 2013
Today's high throughput sequencing approaches, coupled with equally revolutionary advances in bioinformatics, allow us to describe and analyze genomes in unprecedented detail. Short Read Sequencing (SRS) approaches have been especially instrumental in bringing genomic analysis to a wide range of questions and species in plant biology.
Ben, Hunter, Kevin M, Wright, Kirsten, Bomblies   +2 more
openaire   +2 more sources

RNA Sequencing Protocols for Short-Read Sequencing

RNA sequencing (RNA-seq) methodologies allow the discovery of novel variants and transcripts. These comprise three general steps: (1) capture of RNA species of interest, (2) conversion of RNA to complementary DNA (cDNA), and (3) modification of cDNA to fit the sequencing platform.
Laura, Vasquez-Velez, Veera, D'Mello, Patricia, Soteropoulos   +2 more
openaire   +2 more sources

Efficient short-read sequencing on long-read sequencers

2020
We present SMURF-seq, a protocol to efficiently sequence short DNA molecules on a long-read sequencer by randomly ligating them to form long molecules. Applying SMURF-seq using the highly portable and inexpensive Oxford Nanopore MinION yields up to 30 fragments per read, providing an average of 6.2 and up to 7.5 million mappable fragments per run ...
openaire   +1 more source

Probability Model for Boundaries of Short-Read Sequencing

2012 International Conference on Advances in Computing and Communications, 2012
The need for sequencing DNA has been growing tremendously over the past few years. Current next-generation sequencing techniques produce huge amounts of data but time and money remain limiting factors for researchers. Given a DNA sample, it is essential to produce a sufficient number of reads to create or recreate a digital representation of the DNA ...
Florian Schatz, Lars Wienbrandt, Manfred Schimmler   +2 more
openaire   +1 more source