Results 151 to 160 of about 213,259 (308)

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Integrative clustering by colonic volatile fatty acids reveals microbiota and host physiological variation in weaned piglets

Journal of Animal Science and Biotechnology
Background Volatile fatty acids (VFAs) reflect microbial fermentation linking gut microbiota, metabolism and host physiology. However, endogenous VFA profiles and their physiological relevance remain insufficiently characterized.
Chengcheng Li, Stijn Heirbaut, Joris Michiels, Yuhuang Hou, Anneke Ovyn, Noémie Van Noten, Elout Van Liefferinge, Jeroen Degroote   +7 more
doaj   +1 more source

The effects of parenteral or dietary omega-3 polyunsaturated fatty acids in rat models of spinal cord injury

, 2010
PhDThere is currently no effective treatment for spinal cord injury (SCI). Long chain omega-3 polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects in various neurological disorders.
Hall, Jodie Christine Elizabeth
core  

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Fatty acid distribution in salamanders of the family Plethodontidae

, 1975
Fatty acid distributions in tissues from salamanders of the family Plethodontidae were compared to determine the feasibility of using such differences as a taxonomic tool. Intraspecific, generic, and interspecific variations in the fatty acid composition
Lank, Doyal R.
core  

Effects of dietary fatty acids, polyunsaturated/saturated ratios, and fat levels on growth and mineral deposition in young male rats [PDF]

, 1990
The purpose of this study was to investigate dietary effects of short-chain saturated (SCSFA), long-chain saturated (LCSFA), longchain monounsaturated (LCMFA), and long-chain polyunsaturated (LCPFA) fatty acids on growth and mineral status in male ...
D'Souza, Deborah M., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Acetate uptake alleviates propionate-mediated growth restriction in Yersinia enterocolitica

Infection and Immunity
The gut microbiota impedes infection by enteric pathogens, a process termed colonization resistance. Microbial production of short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, contributes to colonization resistance.
Matthew K. Muramatsu, Dylan Cole, Sebastian J. Perez-Orozco, Sebastian E. Winter   +3 more
doaj   +1 more source

Differential modulation of enterocyte-like Caco-2 cells after exposure to short-chain fatty acids

, 2003
The response of intestinal epithelial cells to short-chain fatty acids, which are increasingly used as food additives, was investigated. Human small intestinal epithelial cell model Caco-2 cells were exposed to formate, propionate and butyrate to assess ...
Koninkx, J.F.J.G., van Dijk, J.E., Veldman, K.T., Douma, P.M., Malago, J.J., Dijk, J.E., van, Dirkzwager, A., Hendriks, H.G.C.J.M.   +7 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source