Results 51 to 60 of about 3,382,481 (279)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Collective evolution characteristics and computer simulation of short fatigue cracks

, 1997
Fatigue testing was conducted using a kind of triangular isostress specimen to obtain the short-fatigue-crack behaviour of a weld low-carbon steel. The experimental results show that short cracks continuously initiate at slip bands within ferrite grain ...
白以龙, Fang B, 洪友士, Gu ZY
core   +2 more sources

In situ measurement of fatigue crack opening stresses by nonlinear vibro-acoustic modulation testing

Advances in Mechanical Engineering, 2017
The difficulty of accurately measuring crack closure regions has hindered measurements of opening or closure stresses, and ultrasonic methods have shown great potentialities in evaluating closure area. Many recent researches have confirmed the advantages
Jun Jia, Haifeng Hu, Limin Tao, Yongpan Hu   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Research on the dynamic characteristics and disaster mechanism of anti-slide short pile-supported slopes

Scientific Reports
The terrain in Southwest China is predominantly mountainous with many slopes requiring reinforcement. This region also experiences frequent rainfall and earthquakes, which can trigger landslides. Therefore, studies on slope reinforcement are crucial.
Yuan Liu, Jie Lai, Yun Liu
doaj   +1 more source

Regularities in propagation of opened corrosion‐induced cracks in concrete

Journal of Civil Engineering and Management, 2007
Long and short‐term (accelerated with simulation of pressure developed by compressed rust) experimental investigations were accomplished. It was investigated in long‐term tests the relationship between the width of the longitudinal cracks on the concrete
Vidmantas Jokūbaitis
doaj   +1 more source

Is notch sensitivity a stress analysis problem? [PDF]

Fracture and Structural Integrity, 2013
Semi–empirical notch sensitivity factors q have been widely used to properly account for notch effects in fatigue design for a long time. However, the intrinsically empirical nature of this old concept can be avoided by modeling it using sound mechanical
Jaime Tupiassú Pinho de Castro, Marco Antonio Meggiolaro   +1 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source