Results 61 to 70 of about 3,382,481 (279)

Experimental study on seismic characteristics of slope supported by long-short composite anti-slide piles

Scientific Reports
In this study, a shaking table test was conducted on long-short composite anti-slide piles, the development process and dynamic response of cracks in a pile-supported slope were observed, and the failure mechanism of the slope was explored.
Jie Lai, Yun Liu, Yuan Liu, Xu Jiangbo
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

On the Short Surface Fatigue Crack Growth Behavior in a Fine-Grained WC-Co Cemented Carbide

Metals, 2017
In the present study, the fatigue crack growth (FCG) behavior of short surface cracks in a fine-grained cemented carbide with a length of less than 1 mm was investigated.
Hiroko Mikado, Sotomi Ishihara, Noriyasu Oguma, Shingo Kawamura   +3 more
doaj   +1 more source

Simulation of CO₂ injection into sandstone lens sealing based on 2D crack expansion

矿业科学学报, 2020
To ensure the safety of supercritical carbon dioxide storage in sandstone lens bodies, the initiation, propagation and evolution of cracks were studied.A lenticular geological model and a numerical calculation model were established to analyze the ...
Yu Hui, Cui Zhendong, Ding Hanghang, Yao Yi, Pang Zhenzhong, Zhu Ke   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Monitoring and Analysis of Crack Dimensions in Prestressed Concrete T-Girders on the Western Sichuan Plateau

Buildings
Beam bridges in mountainous and high-altitude transport corridors are frequently exposed to large diurnal temperature differences, intense solar radiation, low humidity, freeze–thaw action and repeated wetting–drying cycles.
Yicheng Zhao, Nuo Xu, Xiaojun Zhou
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source