Results 111 to 120 of about 1,244,170 (347)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Short term fluctuations of wind and solar power systems

New Journal of Physics, 2016
Wind and solar power are known to be highly influenced by weather events and may ramp up or down abruptly. Such events in the power production influence not only the availability of energy, but also the stability of the entire power grid.
M Anvari, G Lohmann, M Wächter, P Milan, E Lorenz, D Heinemann, M Reza Rahimi Tabar, Joachim Peinke   +7 more
doaj   +1 more source

Non equilibrium steady states: fluctuations and large deviations of the density and of the current

, 2007
These lecture notes give a short review of methods such as the matrix ansatz, the additivity principle or the macroscopic fluctuation theory, developed recently in the theory of non-equilibrium phenomena.
Alcaraz F C, Andjel E D, Bernard Derrida, Blythe R A, Bodineau T, Bonetto F, Borodin A Ferrari P L Prahofer M Sasamoto T, Boutillier C, Brak R, Demasi A, Dembo A, Derrida B, Derrida B, Derrida B, Derrida B, Eckmann J P, Ellis R, Essler F H L, Evans M R, Evans M R, Ferrari P A, Golinelli O, Golinelli O, Hakim V, Harris R J, Harris R J, Hinrichsen H, Isaev A P, Kipnis C, Klumper A, Kolomeisky A B, Krebs K, Kurchan J, Lepri S, Liggett T, Mallick K, Mallick K, Popkov V, Povolotsky A M, Prahofer M, Sasamoto T, Sasamoto T, Speer E R, Spohn H, Spohn H, Visco P   +45 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Hydrogen-bonded Silica Gels Dispersed in a Smectic Liquid Crystal: A Random Field XY System

, 2001
The effect on the nematic to smectic-A transition in octylcyanobiphenyl (8CB) due to dispersions of hydrogen-bonded silica (aerosil) particles is characterized with high-resolution x-ray scattering. The particles form weak gels in 8CB creating a quenched
B.J. Frisken, B.M. Ocko, C. W. Garland, C.W. Garland, D.S. Fisher, D.S. Fisher, G. Grinstein, G. S. Iannacchione, G.S. Iannacchione, J.-L. Gallani, L. Radzihovsky, L. Wu, M. Aizenman, M. Chan, Q. Feng, R. J. Birgeneau, R. L. Leheny, R.A. Pelcovits, R.J. Birgeneau, R.J. Birgeneau, S. Park, T. Bellini, T. Bellini, T. Jin, Y. Imry   +24 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A short and simple bedside test to detect cognitive fluctuations in patients with dementia with Lewy bodies. [PDF]

, 2023
Kurt Segers, Florence Benoit, Francisco de Assis Oliveira Rocha, Jean‐Philippe Praet, Murielle Surquin   +4 more
openalex   +1 more source

Surface Fluctuations of an Aging Colloidal Suspension: Evidence for Intermittent Quakes

, 2009
We present measurements of the thermal fluctuations of the free surface of an aging colloidal suspension, Laponite. The technique consists in measuring the fluctuations of the position of a laser beam that reflects from the free surface.
Frétigny, Christian, Lequeux, François, Mamane, Alexandre, Talini, Laurence   +3 more
core   +3 more sources