Results 211 to 220 of about 3,914,190 (307)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
CEEMDAN-decomposed time series forecasting of reported hepatitis B cases using KOA-optimised deep learning: a nationwide study in mainland China (2004-2027). [PDF]
J Glob HealthWang Z +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance. [PDF]
Med Sci (Basel)Barshtein G +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Long-Duration Response to Levodopa in Patients with Early Parkinson's Disease: Pharmacodynamics, Neuroplasticity, and Clinical Implications. [PDF]
BiomedicinesSciacca G.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Filtering Short Term Fluctuations in Inflation Analysis
Many economic time series, specifically inflation, are inherently subject to seasonal fluctuations which obscure the real changes of the series. In this respect, seasonal adjustment is a powerful tool when removing such fluctuations.
H. Cagri Akkoyun +3 more
core
Reconstructing community dynamics from limited observations. [PDF]
MicrobiomeRoss C +6 more
europepmc +1 more source