Results 61 to 70 of about 312,657 (243)

Chromosome-Level Genome Assembly and Annotation of Piptanthus nepalensis (Hook.) Sweet

Scientific Data
Piptanthus nepalensis (Hook.) Sweet is a leguminous shrub native to the Himalayan region and is valued for its medicinal uses and ornamental yellow flowers. Here, we report a chromosome-scale genome assembly of P.
Jiayin Zhang, Zhefei Zeng, Ngawang Bonjor, Ngawang Norbu, Norzin Tso, Xin Tan, Yuguo Wang, Junwei Wang, La Qiong   +8 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Improved genome assembly of Onygena corvina, a keratin-degrading fungus

BMC Research Notes
Objective Onygena corvina is a non-pathogenic, saprophytic fungus that colonizes feathers, hooves, and hair, and represents a valuable source of keratin-degrading enzymes. The only genome assembly of O.
Siddhi Pavale, Vincent G. H. Eijsink, Sabina Leanti La Rosa   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Chromosome-scale genome assembly and de novo annotation of Alopecurus aequalis

Scientific Data
Alopecurus aequalis is a winter annual or short-lived perennial bunchgrass which has in recent years emerged as the dominant agricultural weed of barley and wheat in certain regions of China and Japan, causing significant yield losses.
Jonathan Wright, Kendall Baker, Tom Barker, Leah Catchpole, Alex Durrant, Fiona Fraser, Karim Gharbi, Christian Harrison, Suzanne Henderson, Naomi Irish, Gemy Kaithakottil, Ilia J. Leitch, Jun Li, Sacha Lucchini, Paul Neve, Robyn Powell, Hannah Rees, David Swarbreck, Chris Watkins, Jonathan Wood, Seanna McTaggart, Anthony Hall, Dana MacGregor   +22 more
doaj   +1 more source

Whole-genome re-sequencing of the Baikal seal and other phocid seals for a glimpse into their genetic diversity, demographic history, and phylogeny

GigaByte
The Baikal seal (Pusa sibirica) is a freshwater seal endemic to Lake Baikal, where it became landlocked million years ago. It is an abundant species of least concern despite the limited habitat.
Marcel Nebenführ , Ulfur Arnason , Axel Janke   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A high-quality Chromosome-level genome assembly of Gynostemma guangxiense (Cucurbitaceae)

Scientific Data
Gynostemma guangxiense X. X. Chen & D. H. Qin, belonging to the family Cucurbitaceae, is a perennial creeping herbaceous plant endemic to China with potential medicinal and health value.
Xiao Zhang, Hao Zhang, Chen Chen, Yuemei Zhao   +3 more
doaj   +1 more source