Results 81 to 90 of about 6,347,071 (258)

Fast and accurate discovery of degenerate linear motifs in protein sequences. [PDF]

PLoS ONE, 2014
Linear motifs mediate a wide variety of cellular functions, which makes their characterization in protein sequences crucial to understanding cellular systems.
Abdellali Kelil, Benjamin Dubreuil, Emmanuel D Levy, Stephen W Michnick   +3 more
doaj   +1 more source

Prediction of short linear protein binding regions [PDF]

, 2011
Short linear motifs in proteins (typically 3–12 residues in length) play key roles in protein–protein interactions by frequently binding specifically to peptide binding domains within interacting proteins.
Pollastri, Gianluca, Haslam, Niall J., Denis C. Shields, Niall J. Haslam, Catherine Mooney, Gianluca Pollastri, Shields, Denis C., Mooney, Catherine   +7 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase.

PLoS ONE, 2020
Protein domains often recognize short linear protein motifs composed of a core conserved consensus sequence surrounded by less critical, modulatory positions.
Pau Jané, Gergő Gógl, Camille Kostmann, Goran Bich, Virginie Girault, Célia Caillet-Saguy, Pascal Eberling, Renaud Vincentelli, Nicolas Wolff, Gilles Travé, Yves Nominé   +10 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

De Novo Short linear motif discovery: Implications for disease understanding and drug discovery in Malaria

, 2012
Short linear motifs in proteins of 3-8 residues in length play key roles in protein-protein interactions, frequently binding specifically to peptide-binding domains within interacting proteins.
Catherine Mooney (76525), Denis Shields (98242), Niall Haslam (98217)   +2 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

MEME-LaB : motif analysis in clusters [PDF]

, 2013
Genome-wide expression analysis can result in large numbers of clusters of co-expressed genes. While there are tools for ab initio discovery of transcription factor binding sites, most do not provide a quick and easy way to study large numbers of ...
Paul Brown, Baxter, Laura, Jim Beynon, Jonathan D. Moore, Moore, Jonathan D., Brown, Paul E., Sascha Ott, Hickman, Richard J., Ott, Sascha, Beynon, Jim, Laura Baxter, Richard Hickman   +11 more
core   +1 more source

replication-package-motif-action-study.zip

, 2023
 Replication package for motif action study. 
M A (13993116)
core   +1 more source