The Impact of the Long-Distance Transport of a BEL1-Like Messenger RNA on Development [PDF]
, 2012 BEL1- and KNOTTED1-type proteins are transcription factors from the three-amino-loop-extension superclass that interact in a tandem complex to regulate the expression of target genes.
Gonzalez, Daniel Hector +4 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Prediction of virus-host protein-protein interactions mediated by short linear motifs [PDF]
BMC Bioinformatics, 2017 Des motifs linéaires courts dans les protéines des organismes hôtes peuvent être imités par les virus pour créer des interactions protéine-protéine qui désactivent ou contrôlent les voies métaboliques. Étant donné que les instances de motifs linéaires viraux d'expressions régulières de motifs hôtes peuvent être trouvées par hasard, il est nécessaire de
Andrés Becerra +2 more
openaire +2 more sources
Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo
Cell Reports Methods, 2023 Peptide-domain interactions mediated by short linear motifs (SLiMs) play crucial roles in cellular biology. The simplicity of SLiMs poses challenges in their computational identification. Existing high-throughput methods for discovering SLiMs lack cellular context as they are typically performed in vitro.
Tanner M. Tessier +2 more
openaire +3 more sources
The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]
, 2011 Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman +8 more
core +1 more source
Structure and Magnetic Properties of a 1D Alternating Cu(II) Monomer―Paddlewheel Chain [PDF]
, 2018 One-dimensional metal–organic coordination polymers make up a class of compounds with potential towards the development of practical, new magnetic materials.
Dawe, Louise N. +2 more
core +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Stable Propagation of a Burst Through a One-Dimensional Homogeneous Excitatory Chain Model of Songbird Nucleus HVC [PDF]
, 2006 We demonstrate numerically that a brief burst consisting of two to six spikes can propagate in a stable manner through a one-dimensional homogeneous feedforward chain of non-bursting neurons with excitatory synaptic connections.
C. K. Catchpole +25 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Single-Molecule Analysis of i-motif Within Self-Assembled DNA Duplexes and Nanocircles [PDF]
, 2019 The cytosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are prevalent in genomic DNA. Recent studies of i-motif–forming sequences have shown increasing evidence of their roles in gene regulation.
Cox, Bobby D. +6 more
core +1 more source