Results 31 to 40 of about 2,082 (217)

Photocatalytic Water Splitting on the Lunar Surface: Prospects for In Situ Resource Utilization

Advanced Materials Interfaces, EarlyView.
Water has been found in craters on the moon nearby locations which are illuminated >80% of the time. Photocatalysis uses energy from sunlight to drive chemical reactions such as water splitting to produce oxygen and hydrogen. It is a scalable technology that requires lighter equipment and utilizes resources available on the moon. ABSTRACT The discovery
Ranjani Kalyan, Thomas D. Small, Gregory F. Metha, Mahmoud Adel Hamza, Thomas J. O'Dea, Yideng Shen, Cameron J. Shearer   +6 more
wiley   +1 more source

The Return of the Rosetta Target: Keck Near-infrared Observations of Comet 67P/Churyumov–Gerasimenko in 2021

The Astronomical Journal, 2023
High-resolution near-infrared ground-based spectroscopic observations of comet 67P/Churyumov–Gerasimenko near its maximum activity in 2021 were conducted from the W. M. Keck Observatory, using the facility spectrograph NIRSPEC.
Boncho P. Bonev, Neil Dello Russo, Hideyo Kawakita, Ronald J. Vervack Jr., Michael A. DiSanti, Yoshiharu Shinnaka, Takafumi Ootsubo, Erika L. Gibb, Michael R. Combi, Kathrin Altwegg, Nicolas Biver, Jacques Crovisier, Gregory Doppmann, Geronimo L. Villanueva, Younas Khan, Chemeda T. Ejeta, Mohammad Saki, Adam J. McKay, Anita L. Cochran, Emmanuel Jehin, Nathan X. Roth, Martin A. Cordiner, Yinsi Shou   +22 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Ice, Ice, Maybe? Investigating 46P/Wirtanen’s Inner Coma for Icy Grains

The Planetary Science Journal, 2023
The release of volatiles from comets is usually from direct sublimation of ices on the nucleus, but for very or hyperactive comets other sources have to be considered to account for the total production rates.
Theodore Kareta, John W. Noonan, Walter M. Harris, Alessondra Springmann   +3 more
doaj   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Reversal of Spin: Comet 41P/Tuttle–Giacobini–Kresak

The Astronomical Journal
The rotations of cometary nuclei are known to change in response to outgassing torques. The nucleus of the Jupiter-family comet 41P/Tuttle–Giacobini–Kresak exhibited particularly dramatic rotational changes when near perihelion in 2017 April.
David Jewitt
doaj   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Comprehensive Analyses of the Strongly Carbon-chain Depleted Comets in Lowell Observatory’s Narrowband Photometry Database

The Planetary Science Journal
We present measurements, analyses, and results for the 17 strongly carbon-chain depleted comets in Lowell Observatory’s narrowband photometry database.
Allison N. Bair, David G. Schleicher
doaj   +1 more source