Results 41 to 50 of about 2,437 (254)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Activity of 50 Long-Period Comets Beyond 5.2 AU [PDF]

, 2016
Remote investigations of the ancient solar system matter has been traditionally carried out through the observations of long-period (LP) comets that are less affected by solar irradiation than the short-period counterparts orbiting much closer to the Sun.
Kelemen, János, Csák, B, Szalai, T, Vinkó, J, Marschalkó, Gábor, Székely, Péter, Székely, P, Szakáts, Róbert, Kiss, L. László, Vida, Krisztián, Sárneczky, K, Szabó, GyM, Kiss, LL, Marschalkó, G, Sárneczky, Krisztián, Kelemen, J, Pál, A, Szakáts, R, Szalai, Tamás, Vinkó, József, Szegedi-Elek, E, Szegedi-Elek, Elza, Szabó M., Gyula, Vida, K, Pál, András, Csák, Balázs   +25 more
core   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Reversal of Spin: Comet 41P/Tuttle–Giacobini–Kresak

The Astronomical Journal
The rotations of cometary nuclei are known to change in response to outgassing torques. The nucleus of the Jupiter-family comet 41P/Tuttle–Giacobini–Kresak exhibited particularly dramatic rotational changes when near perihelion in 2017 April.
David Jewitt
doaj   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Short-period Jupiter family comets after Stardust

, 2008
The NASA Stardust mission has provided for laboratory study an extensive data set of cometary dust of known provenance (from comet 81P/Wild 2) yielding detailed insights into the composition of the comet.
Kearsley, Anton T., Burchell, Mark J.
core   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

The Evolution of Activity and Chemical Composition in Rosetta’s Comet Targets across Multiple Apparitions: Complications for CS2 as the CS Parent in Comet Nuclei

The Planetary Science Journal, 2023
Jupiter-family comets are ephemeral small bodies injected into the inner solar system from the Kuiper Belt, doomed to either sublimate all their volatiles and become inert or violently shatter from the activity.
John W. Noonan, Joel Wm. Parker, Walter M. Harris, Steven Bromley, Mohammad Saki, Youssef Moulane, Davide Farnocchia, Marco Micheli, Jian-Yang Li, Kathleen E. Mandt, Kumar Venkataramani, Dennis Bodewits   +11 more
doaj   +1 more source

Long Dust Trails of Short Period Comets [PDF]

International Astronomical Union Colloquium, 1991
Comets constitute an important source for the zodiacal dust cloud. Mainly large particles are contributed because the smaller particles are emitted into hyperbolic orbits relative to the sun. Radiation pressure force reduces the effective solar gravitational attraction. Information about large cometary particles can be derived from a variety of sources
H. U. Keller, K. Richter
openaire   +1 more source

Alternative Policy Designs to Help Farmers Select Profitable Conservation Practices

Agribusiness, EarlyView.
ABSTRACT Voluntary private carbon initiatives (VPCIs) promote the implementation of agricultural conservation practices that mitigate emissions of greenhouse gases (GHGs) via financial incentives to participating farmers. Simultaneously, an array of public policies supports the adoption of conservation practices through technical and financial ...
Oranuch Wongpiyabovorn, Alejandro Plastina   +1 more
wiley   +1 more source