Results 111 to 120 of about 154,252 (307)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Creating agile supply chains in the fashion industry. [PDF]
, 2004 Fashion markets are synonymous with rapid change and, as a result, commercial success or failure in those markets is largely determined by the organisation’s flexibility and responsiveness.
Christopher, Martin +2 more
core +1 more source
Financing Newsvendor with Trade Credit and Bank Credit Portfolio
MathematicsTrade credit is a crucial component of supply chain financing, enabling businesses to manage cash flow and optimize inventory levels. This study delves into the application and implications of multiple trade credit types with different repayment periods ...
Yue Zhang, Bin Zhang, Rongguang Chen
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Smart Logistics Model for Supply Chain Management via Brain-Inspired Geometric Deep Networks
BiomimeticsSystematic logistics plays a key role in fostering profitable development in supply chains. An intelligent logistics model can help create a more agile, sustainable, and resilient supply chain.
Mehdi Khaleghi +5 more
doaj +1 more source
Digitalization and Short Food Supply Chains in Hungary
European CountrysideAbstract The study focuses on the relationship between local producers and consumers in agri-food chains and the future potential of online sales channels in the rural economy through the example of a Hungarian micro-region. The paper categorises the Hungarian micro-regions and identifies the districts that could be considered for the
Krisztián Ritter, Zsolt Ádám Orbán
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Coordination of new product development and supply chain management
, 2018 New product development (NPD) and supply chain management (SCM) enable companies to respond to new demands in a responsive manner. The scarcity of research addressing the coordination of NPD and SCM is notable. The purpose of this research is to identify
Hilletofth, Per, +4 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
A Model for Proactive Supply Chain Risk Management
, 2007 Increasingly, companies need to be vigilant with the risksthat could harm the short-term operations as well as thelong-term sustainability of their supply chain.
Geraldin, Laudine H., Pujawan, I. Nyoman
core +1 more source