Results 61 to 70 of about 3,711,281 (293)

Microsatellite typing of Mycobacterium leprae strains in newly diagnosed multibacillary leprosy patients to trace out the transmission pattern

Biomedical and Biotechnology Research Journal, 2017
Background: Leprosy was eliminated from India in December 2005 imprinting a prevalence rate of
Farah Naaz, Partha Sarathi Mohanty, Avi Kumar Bansal, Dilip Kumar, Umesh Datta Gupta   +4 more
doaj   +1 more source

REViewer: haplotype-resolved visualization of read alignments in and around tandem repeats

Genome Medicine, 2022
Background Expansions of short tandem repeats are the cause of many neurogenetic disorders including familial amyotrophic lateral sclerosis, Huntington disease, and many others.
Egor Dolzhenko, Ben Weisburd, Kristina Ibañez, Indhu-Shree Rajan-Babu, Christine Anyansi, Mark F. Bennett, Kimberley Billingsley, Ashley Carroll, Samuel Clamons, Matt C. Danzi, Viraj Deshpande, Jinhui Ding, Sarah Fazal, Andreas Halman, Bharati Jadhav, Yunjiang Qiu, Phillip A. Richmond, Christopher T. Saunders, Konrad Scheffler, Joke J. F. A. van Vugt, Ramona R. A. J. Zwamborn, Genomics England Research Consortium, Samuel S. Chong, Jan M. Friedman, Arianna Tucci, Heidi L. Rehm, Michael A. Eberle   +26 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Advanced Interferometric SAR Techniques with TanDEM-X [PDF]

, 2008
TanDEM-X is an innovative mission with a TerraSAR-X add-on satellite for high-resolution singlepass SAR interferometry. The TanDEM-X mission has the primary objective of generating a consistent, global DEM with an unprecedented accuracy according to the ...
Hajnsek, Irena, Fiedler, Hauke, Hauke Fiedler, Krieger, Gerhard, Irena Hajnsek, Marwan Younis, Manfred Zink, Werner, Marian, Alberto Moreira, Zink, Manfred, Moreira, Alberto, Younis, Marwan, Gerhard Krieger, Marian Werner   +13 more
core   +1 more source

Short tandem repeat (STR) analysis of skin fibroblasts GM02948 and their isogenic iPSC clones.

, 2022
Short tandem repeat (STR) analysis of skin fibroblasts GM02948 and their isogenic iPSC clones.
Hirofumi Ohashi (9187894), Tatsuo Miyamoto (12225655), Keita Tomioka (12225661), Hiroshi Ochiai (2702584), Shinya Matsuura (122522), Silvia Natsuko Akutsu (12225652), Daiju Oba (12225658)   +6 more
core   +1 more source

GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer’s disease

Nature Communications
GWAS typically focus on SNPs, often excluding complex genetic variants, such as short tandem repeats. Here, we report the results of GWAS analyses systematically assessing the role of short tandem repeats, both imputed and directly genotyped by whole ...
David Gmelin, Olena Ohlei, M. Muaaz Aslam, Marit P. Junge, Laura Parkkinen, Kristina Mullin, Dmitry Prokopenko, Christina M. Lill, Rudolph E. Tanzi, Valerija Dobricic, Lars Bertram   +10 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Hybrid de novo tandem repeat detection using short and long reads [PDF]

, 2015
International audienceBackgroundAs one of the most studied genome rearrangements, tandem repeats have a considerable impact on genetic backgrounds of inherited diseases. Many methods designed for tandem repeat detection on reference sequences obtain high
Guillaume Fertin, Radulescu, Andreea, Jean, Géraldine, Rusu, Irena, Géraldine Jean, Andreea Radulescu, Irena Rusu, Fertin, Guillaume   +7 more
core   +2 more sources

Clinical and mechanism research progress on short tandem repeat ⁃ related neuromuscular diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Short tandem repeat (STR) is a component of the human genome, the number of repeats of STR is prone to change during DNA replication, and when it exceeds a certain threshold, it will lead to the occurrence of diseases, most of which involve the nervous ...
WAN Ya‑lan, YU Jia‑xi, DENG Jian‑wen, HONG Dao‑jun, WANG Zhao‑xia   +4 more
doaj   +1 more source