Results 51 to 60 of about 3,711,281 (293)

X-Chromosome short tandem repeat, advantages and typing technology review [PDF]

, 2015
Microsatellites of the X-chromosome have been increasingly studied in recent years as a useful tool in forensic analysis. This review describes some details of X-chromosomal short tandem repeat (STR) analysis.
Kareem, MA, Hameed, IH, Rafid, HH
core   +1 more source

Mapping the landscape of tandem repeat variability by targeted long read single molecule sequencing in familial X-linked intellectual disability

BMC Medical Genomics, 2018
Background The etiology of more than half of all patients with X-linked intellectual disability remains elusive, despite array-based comparative genomic hybridization, whole exome or genome sequencing.
Alena Zablotskaya, Hilde Van Esch, Kevin J. Verstrepen, Guy Froyen, Joris R. Vermeesch   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

lobSTR: A Short Tandem Repeat Profiler for Personal Genomes [PDF]

Genome Research, 2012
Short tandem repeats (STRs) have a wide range of applications, including medical genetics, forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to profile hundreds of thousands of STR loci. However, mainstream bioinformatics pipelines are inadequate for the task.
Melissa Gymrek, David Golan, Saharon Rosset, Yaniv Erlich   +3 more
openaire   +2 more sources

Turkish population data on the short tandem repeat locus TPOX

, 1998
Udgivelsesdato: 1998-nullAllele and genotype frequencies were determined for the STR (short tandem repeat) locus TPOX in a random Turkish population sample of 200 ...
Morling, N, Atlioglu, E, Poda, M, Kolusayin, O, Cenani, A, Tümer, Z, Vural, B   +6 more
core   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Integrated multiple sequence alignment [PDF]

, 2005
Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core  

Flight Dynamics Operations of the TanDEM-X Formation [PDF]

, 2012
Since end of 2010 the German TerraSAR-X and TanDEM-X satellites are routinely operated as the first configurable single-pass Synthetic Aperture Radar interferometer in space. The two 1340 kg satellites fly in a 514 km sun-synchronous orbit.
Aida, Saika, Schlepp, Benjamin, Kirschner, Michael, Kahle, Ralph, Wermuth, Martin   +4 more
core   +1 more source

Systematic profiling of short tandem repeats in the cattle genome [PDF]

Genome Biology and Evolution, 2016
Short tandem repeats (STRs), or microsatellites, are genetic variants with repetitive 2–6 base pair motifs in many mammalian genomes. Using high-throughput sequencing and experimental validations, we systematically profiled STRs in five Holsteins.
Xu, Lingyang, Haasl, Ryan J., Sun, Jiajie, Zhou, Yang, Bickhart, Derek M., Li, Junya, Song, Jiuzhou, Sonstegard, Tad S., Van Tassell, Curtis P., Lewin, Harris A., Liu, George E.   +10 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source