Results 71 to 80 of about 10,714 (176)

SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin

Journal of Cancer Research and Clinical Oncology
Purpose Growing evidence suggests that the tyrosine phosphatase SHP2 is pivotal for tumor progression. Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, characterized by its high recurrence rate, aggressive metastasis, and
Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou   +4 more
doaj   +1 more source

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

Neural Regeneration Research
Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by PTPN11, is widely expressed in the ...
Xintian Ding, Chun Chen, Heng Zhao, Bin Dai, Lei Ye, Tao Song, Shuai Huang, Jia Wang, Tao You   +8 more
doaj   +1 more source

WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer

npj Precision Oncology
Protein tyrosine phosphatase SHP2 activates RAS signaling, which is a novel target for colorectal cancer (CRC) therapy. However, SHP2 inhibitor monotherapy is ineffective for metastatic CRC and a combination therapy is required.
Hao Fan, Xuefei Hu, Fuao Cao, Leqi Zhou, Rongbo Wen, Hao Shen, Yating Fu, Xiaoming Zhu, Hang Jia, Zixuan Liu, Guimin Wang, Guanyu Yu, Wenjun Chang, Wei Zhang   +13 more
doaj   +1 more source

Study on SHP2 Conformational Transition and Structural Characterization of Its High-Potency Allosteric Inhibitors by Molecular Dynamics Simulations Combined with Machine Learning

Molecules
The src-homology 2 domain-containing phosphatase 2 (SHP2) is a human cytoplasmic protein tyrosine phosphatase that plays a crucial role in cellular signal transduction. Aberrant activation and mutations of SHP2 are associated with tumor growth and immune
Baerlike Wujieti, Mingtian Hao, Erxia Liu, Luqi Zhou, Huanchao Wang, Yu Zhang, Wei Cui, Bozhen Chen   +7 more
doaj   +1 more source

Dual Allosteric Inhibition of SHP2 Phosphatase

ACS Chemical Biology, 2018
SHP2 is a cytoplasmic protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell proliferation, differentiation, and survival. Recently, we reported an allosteric mechanism of inhibition that stabilizes the auto-inhibited conformation of SHP2.
Michelle Fodor, Edmund Price, Ping Wang, Hengyu Lu, Andreea Argintaru, Zhouliang Chen, Meir Glick, Huai-Xiang Hao, Mitsunori Kato, Robert Koenig, Jonathan R. LaRochelle, Gang Liu, Eric McNeill, Dyuti Majumdar, Gisele A. Nishiguchi, Lawrence B. Perez, Gregory Paris, Christopher M. Quinn, Timothy Ramsey, Martin Sendzik, Michael David Shultz, Sarah L. Williams, Travis Stams, Stephen C. Blacklow, Michael G. Acker, Matthew J. LaMarche   +25 more
openaire   +3 more sources

Screening of tyrosine phosphatase SHP2 (PTPN11) inhibitors from natural products with therapeutic potential for receptor tyrosine kinase-driven cancer

Journal of Pharmaceutical Analysis
Src homology 2 domain-containing phosphatase 2 (SHP2) is a pivotal regulator linking receptor tyrosine kinase (RTK) signaling. Abnormal SHP2 activity has been associated with tumorigenesis and metastasis.
Lingfeng Chen, Di Ke, Zheng Jiang, Ruixiang Luo, Jie Li, Lulu Zheng, Guang Liang   +6 more
doaj   +1 more source

Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons

Cell Death and Disease
Shp2, a critical SH2-domain-containing tyrosine phosphatase, is essential for cellular regulation and implicated in metabolic disruptions, obesity, diabetes, Noonan syndrome, LEOPARD syndrome, and cancers.
Ammaji Rajala, Rahul Rajala, Mohd A. Bhat, Mark Eminhizer, Jeff Hao, Jianhai Du, Raju V. S. Rajala   +6 more
doaj   +1 more source

Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β

Scientific Reports, 2017
Toll-like receptor 2 (TLR2) mediates the innate immune response to bacterial lipopeptides and peptidoglycans by stimulating the production of inflammatory cytokines.
Jin Hee Park, Ryeojin Ko, Soo Young Lee
doaj   +1 more source

Thyroid hormone T3 induces Fyn modification and modulates palmitoyltransferase gene expression through αvβ3 integrin receptor in PC12 cells during hypoxia

Translational Neuroscience
Thyroid hormones (THs) are essential in neuronal and glial cell development and differentiation, synaptogenesis, and myelin sheath formation.
Kvergelidze Elisabed, Barbakadze Tamar, Bátor Judit, Kalandadze Irine, Mikeladze David   +4 more
doaj   +1 more source

Spatial interaction and functional status of CD68+SHP2+ macrophages in tumor microenvironment correlate with overall survival of NSCLC

Frontiers in Immunology
BackgroundTumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can regulate tumor proliferation and support resistance to therapy, constituting promising targets for the ...
Xu Liu, Xu Liu, Zengfu Zhang, Jupeng Yuan, Jinming Yu, Jinming Yu, Jinming Yu, Dawei Chen, Dawei Chen   +8 more
doaj   +1 more source