Results 81 to 90 of about 10,714 (176)

SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound

Journal of Orthopaedic Translation
Background: Paraptosis is a novel form of programmed cell death, generally caused by disrupted proteostasis or alterations of redox homeostasis. However, its impact and underlying mechanisms on the pathology of osteoarthritis (OA) are still unclear. This
Wenjie Hou, Xingru Shang, Xiaoxia Hao, Chunran Pan, Zehang Zheng, Yiwen Zhang, Xiaofeng Deng, Ruimin Chi, Jiawei Liu, Fengjing Guo, Kai Sun, Tao Xu   +11 more
doaj   +1 more source

Induced clustering of SHP2-depleted tumor cells in vascular islands restores sensitivity to MEK/ERK inhibition

The Journal of Clinical Investigation
Allosteric inhibitors of the tyrosine phosphatase Src homology 2 domain–containing protein tyrosine phosphatase 2 (SHP2) hold therapeutic promise in cancers with overactive RAS/ERK signaling, but adaptive resistance to SHP2 inhibitors may limit benefits.
Yuyi Wang, Hidetaka Ohnuki, Andy D. Tran, Dunrui Wang, Taekyu Ha, Jing-Xin Feng, Minji Sim, Raymond Barnhill, Claire Lugassy, Michael R. Sargen, Emanuel Salazar-Cavazos, Michael Kruhlak, Giovanna Tosato   +12 more
doaj   +1 more source

SHP2 as a pivotal modulator of the tumor microenvironment in gastrointestinal cancers: from mechanisms to targeted therapies. [PDF]

J Transl Med
Wang S, Zhao X, Dong J, Zhang J, Wang Y, Jin H, Jiang X, Chen L, Zhang M, Ji L, Zhao Y.   +10 more
europepmc   +1 more source

Probing 3-Amino-2H-Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2. [PDF]

ChemMedChem
Amoussa M, Efrém NL, Li F, Guo Z, Roske Y, Frank KJ, Pach S, Wolf CA, Bo F, Lesina M, Kintzel M, Alsalim R, Zeitz V, Csorba N, Radetzki S, Keserű GM, Daumke O, Algül H, Wolber G, Li J, Nazaré M.   +20 more
europepmc   +1 more source

Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants. [PDF]

Sci Adv
van Vlimmeren AE, Giglio RM, Jiang Z, Lee M, McFaline-Figueroa JL, Shah NH.   +5 more
europepmc   +1 more source

SHP2 Inhibitor TNO155 [PDF]

, 2020
openaire   +1 more source

SHP2 in TAMs promoted the survival of gastric adenocarcinoma via suppressing the P38/ERK1/2/SP1/BRD4/STING induced inflammation and ROS. [PDF]

Front Med (Lausanne)
Bai J, Ren H, Zhang Y, Li X.
europepmc   +1 more source

A Multi-Step Computational Workflow for Screening and Prioritizing SHP2-Binding Molecules. [PDF]

Pharmaceuticals (Basel)
Bilotta M, Rocca R, Alcaro S.
europepmc   +1 more source

SHP2: when cardiology meets hematology [PDF]

Blood, 2019
Oury, Cécile, Lancellotti, Patrizio
openaire   +2 more sources

Mapping the SHP2 Allosteric Pocket With Target-Biased Covalent Fragments. [PDF]

Chembiochem
Efrém NL, Csorba N, Amoussa M, Ábrányi-Balogh P, Guo Z, Petri L, Bo F, Di Lorenzo V, Roske Y, Szalai TV, Mihalovits L, Simon J, Li J, Daumke O, Keserű GM, Nazaré M.   +15 more
europepmc   +1 more source